| Gene Information | |
|---|---|
| Gene Name | SRPX2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 465 |
| Protein Names | Sushi repeat-containing protein SRPX2 (Sushi-repeat protein upregulated in leukemia) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000102359 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O60687 |
| Gene Card | SRPX2 |
| Uniprot ID | O60687 |
| Pfam | PF13778; PF02494; PF00084 |
| In ASD | no |
| Allosteric Prediction | no (-0.724221882) |
| Ortholog in Animals | Alpaca_ SRPX2 ( ortholog_one2one ) Dog_ SRPX2 ( ortholog_one2one ) GuineaPig_ SRPX2 ( ortholog_one2one ) Macaque_ SRPX2 ( ortholog_one2one ) Mouse_ Srpx2 ( ortholog_one2one ) Pig_ SRPX2 ( ortholog_one2one ) Rat_ Srpx2 ( ortholog_one2one ) Rabbit_ SRPX2 ( ortholog_one2one ) |
| Ohnologs | SRPX |
| Paralogs | CR1L, SUSD3, F13B, SELP, SEZ6L2, CFHR2, CFHR1, CSMD1, APOH, SELE, SRPX, SVEP1, SEZ6, C8A, CD55, CSMD2, PAPPA2, SUSD6, C4BPA, C9, CR1, PAPPA, SELL, CFB, CD46, C4BPB, CR2, C7, CSMD3, CFHR3, CFH, SEZ6L, CFHR4, CFHR5, C8B, PRF1, SUSD4, C6, C2 |
| Tissue | NA |
| Tissue Specificity | Expressed in neurons of the rolandic area of the brain (at protein level). Highly expressed in the brain, placenta, lung, trachea, uterus, adrenal gland, heart, ovary and placenta. Weakly expressed in the peripheral blood, brain and bone marrow. Expressed in numerous cancer cell lines and in gastrointestinal cancer cells. Higher levels found in colorectal cancers than in normal colonic mucosa. {ECO:0000269|PubMed:16497722, ECO:0000269|PubMed:18718938, ECO:0000269|PubMed:19065654, ECO:0000269|PubMed:22242148, ECO:0000269|PubMed:9864177}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs121918364 rs17851822 rs121918363 |
| Subcellular location [CC] | Secreted. Cytoplasm. Cell surface. Synapse {ECO:0000250}. |
| Mouse PG classification | NA |
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