| Gene Information | |
|---|---|
| Gene Name | KCNE2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 123 |
| Protein Names | Potassium voltage-gated channel subfamily E member 2 (MinK-related peptide 1) (Minimum potassium ion channel-related peptide 1) (Potassium channel subunit beta MiRP1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000159197 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9Y6J6 |
| Gene Card | KCNE2 |
| Uniprot ID | Q9Y6J6 |
| Pfam | PF02060 |
| In ASD | no |
| Allosteric Prediction | no (-0.254544611) |
| Ortholog in Animals | Alpaca_ KCNE2 ( ortholog_one2one ) Dog_ KCNE2 ( ortholog_one2one ) GuineaPig_ KCNE2 ( ortholog_one2one ) Macaque_ KCNE2 ( ortholog_one2one ) Mouse_ Kcne2 ( ortholog_one2one ) Pig_ KCNE2 ( ortholog_one2one ) Rat_ Kcne2 ( ortholog_one2one ) Rabbit_ KCNE2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KCNE1 |
| Tissue | stomach |
| Tissue Specificity | Highly expressed in brain, heart, skeletal muscle, pancreas, placenta, kidney, colon and thymus. A small but significant expression is found in liver, ovary, testis, prostate, small intestine and leukocytes. Very low expression, nearly undetectable, in lung and spleen. {ECO:0000269|PubMed:11034315}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2M0Q (NMR - ) |
| DBSNP | rs2234916 rs35759083 rs16991652 rs142153692 rs199473363 rs74315449 rs148968498 rs74315447 rs74315448 rs16991654 rs199473364 rs199473364 rs16991656 rs199473365 rs141423405 rs74424227 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:20533308}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P63161}. Note=Colocalizes with KCNB1 at the plasma membrane. {ECO:0000250|UniProtKB:P63161}. |
| Mouse PG classification | LPG |
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