| Gene Information | |
|---|---|
| Gene Name | SRPK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 655 |
| Protein Names | SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000096063 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96SB4 |
| Gene Card | SRPK1 |
| Uniprot ID | Q96SB4 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (0.484583318) |
| Ortholog in Animals | Alpaca_ SRPK1 ( ortholog_one2one ) Dog_ SRPK1 ( ortholog_one2one ) GuineaPig_ SRPK1 ( ortholog_one2one ) Mouse_ Srpk1 ( ortholog_one2one ) Pig_ SRPK1 ( ortholog_one2one ) Rat_ Srpk1 ( ortholog_one2one ) Rabbit_ SRPK1 ( ortholog_one2one ) |
| Ohnologs | SRPK2 |
| Paralogs | MAPK8, MAPK10, MAPK1, MAPK6, MAPK12, MAPK13, SRPK3, MAPK4, NLK, MAPK14, MAPK3, MOK, MAPK11, MAK, MAPK15, MAPK7, SRPK2, MAPK9, CILK1 |
| Tissue | NA |
| Tissue Specificity | Isoform 2 is predominantly expressed in the testis but is also present at lower levels in heart, ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 is only seen in the testis, at lower levels than isoform 2. Highly expressed in different erythroid and lymphoid cell lines, with isoform 2 being far more abundant than isoform 1. {ECO:0000269|PubMed:10390541, ECO:0000269|PubMed:11509566, ECO:0000269|PubMed:20708644}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001425(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1WAK (X-ray 1.73A ) 1WBP (X-ray 2.40A ) 3BEG (X-ray 2.90A ) 4WUA (X-ray 2.00A ) 5MXX (X-ray 1.75A ) 5MY8 (X-ray 1.70A ) 5NNG (X-ray 1.20A ) 5XV7 (X-ray 2.32A ) 6FAD (X-ray 2.80A ) 7DD1 (X-ray 2.05A ) 7PQS (X-ray 2.20A ) |
| DBSNP | rs35519113 |
| Subcellular location [CC] | [Isoform 2]: Cytoplasm. Nucleus. Nucleus matrix. Microsome. Note=Shuttles between the nucleus and the cytoplasm. Inhibition of the Hsp90 ATPase activity, osmotic stress and interaction with HHV-1 ICP27 protein can induce its translocation to the nucleus. KAT5/TIP60 inhibits its nuclear translocation.; [Isoform 1]: Cytoplasm. Nucleus matrix. Microsome. Note=Mainly localized in the microsomal fraction and the cytoplasm, and to a lesser extent in the nuclear matrix.; Cytoplasm {ECO:0000269|PubMed:28076779}. Nucleus, nucleoplasm {ECO:0000269|PubMed:28076779}. Nucleus speckle {ECO:0000269|PubMed:28076779}. Chromosome {ECO:0000269|PubMed:28076779}. Note=Preferentially localizes to the promoter of gene coding regions. {ECO:0000269|PubMed:28076779}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |