| Gene Information | |
|---|---|
| Gene Name | SRGAP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1071 |
| Protein Names | SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000266028 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O75044 |
| Gene Card | SRGAP2 |
| Uniprot ID | O75044 |
| Pfam | PF00611; PF00620; PF00018 |
| In ASD | no |
| Allosteric Prediction | no (-0.640182913) |
| Ortholog in Animals | Alpaca_ SRGAP2 ( ortholog_one2one ) Dog_ SRGAP2 ( ortholog_one2many ) Macaque_ SRGAP2 ( ortholog_one2many ) Mouse_ Srgap2 ( ortholog_one2many ) Rat_ Srgap2 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | SRGAP2B, SRGAP2C, SRGAP1, SRGAP3, ARHGAP4 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2DL8 (NMR - ) 4RTT (X-ray 1.87A ) 4RUG (X-ray 1.73A ) 5I6J (X-ray 2.70A ) 5I6R (X-ray 2.15A ) 5I7D (X-ray 3.95A ) |
| DBSNP | rs17018890 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:21148482}. Cell projection, dendritic spine {ECO:0000303|PubMed:22559944}. Postsynaptic density {ECO:0000250|UniProtKB:Q91Z67}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q91Z67}. Cell projection, lamellipodium {ECO:0000269|PubMed:20810653}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q91Z67}. Nucleus {ECO:0000250|UniProtKB:D4A208}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q91Z67}. Note=Recruited to actin-rich phagosomes during phagocytosis (By similarity). Translocates from nucleus to cytoplasm during development (By similarity). {ECO:0000250|UniProtKB:D4A208, ECO:0000250|UniProtKB:Q91Z67}. |
| Mouse PG classification | NA |
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