Gene Information
Gene NameHDAC6
OrganismHomo sapiens (Human)
Gene Length1215
Protein NamesHistone deacetylase 6 (HD6) (EC 3.5.1.98) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)
Target Namehistone deacetylase
Target TypeNA
Gene Age645 ( ENSG00000094631 )
Evolutionary StageEumetazoa
AlphaFoldDBQ9UBN7
Gene CardHDAC6
Uniprot IDQ9UBN7
PfamPF00850; PF02148
In ASDno
Allosteric Predictionyes (1.398446917)
Ortholog in AnimalsDog_ HDAC6 ( ortholog_one2one )
GuineaPig_ HDAC6 ( ortholog_one2one )
Macaque_ HDAC6 ( ortholog_one2one )
Mouse_ Hdac6 ( ortholog_one2one )
Pig_ HDAC6 ( ortholog_one2one )
Rat_ Hdac6 ( ortholog_one2one )
Rabbit_ HDAC6 ( ortholog_one2one )
OhnologsNA
ParalogsHDAC4, HDAC11, HDAC8, HDAC3, HDAC7, HDAC10, HDAC2, HDAC1, HDAC5, HDAC9
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001142(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3C5K  (X-ray  1.55A  3GV4  (X-ray  1.72A  3PHD  (X-ray  3.00A  5B8D  (X-ray  1.05A  5EDU  (X-ray  2.79A  5KH3  (X-ray  1.60A  5KH7  (X-ray  1.70A  5KH9  (X-ray  1.07A  5WBN  (X-ray  1.64A  5WPB  (X-ray  1.55A  6CE6  (X-ray  1.60A  6CE8  (X-ray  1.55A  6CEA  (X-ray  1.60A  6CEC  (X-ray  1.55A  6CED  (X-ray  1.70A  6CEE  (X-ray  1.55A  6CEF  (X-ray  1.80A  7ZYU  (X-ray  2.43A 
DBSNP rs1127346  rs151130423 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:12024216, ECO:0000269|PubMed:24687993}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12024216}. Nucleus {ECO:0000250|UniProtKB:Q9Z2V5}. Perikaryon {ECO:0000250|UniProtKB:Q9Z2V5}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9Z2V5}. Cell projection, axon {ECO:0000250|UniProtKB:Q9Z2V5}. Cell projection, cilium {ECO:0000269|PubMed:17604723}. Note=It is mainly cytoplasmic, where it is associated with microtubules. {ECO:0000269|PubMed:12024216}.
Mouse PG classificationLPG
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