Gene Information
Gene NameSREBP2
OrganismHomo sapiens (Human)
Gene Length1141
Protein NamesSterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)]
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ12772
Gene CardSREBF2
Uniprot IDQ12772
PfamPF00010
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityUbiquitously expressed in adult and fetal tissues. {ECO:0000269|PubMed:7903453}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.003212(Rat);0.044444(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1UKL  (X-ray  3.00A  ) 
DBSNP rs17002714  rs2228314  rs2229440  rs2228313 
Subcellular location [CC][Sterol regulatory element-binding protein 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12202038};
Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000303|PubMed:28849786};
Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000303|PubMed:28849786};
Multi-pass membrane protein {ECO:0000255}. Note=At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum (PubMed:32322062). Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed (PubMed:32322062). {ECO:0000269|PubMed:32322062}.;
[Processed sterol regulatory element-binding protein 2]: Nucleus {ECO:0000269|PubMed:11477106, ECO:0000269|PubMed:32322062}. Note=Transported into the nucleus with the help of importin-beta. Dimerization of the bHLH domain is a prerequisite for importin beta-dependent nuclear import. {ECO:0000250|UniProtKB:Q3U1N2}.
Mouse PG classificationNA
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