| Gene Information | |
|---|---|
| Gene Name | SLC6A12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 614 |
| Protein Names | Sodium- and chloride-dependent betaine transporter (BGT-1) (Na(+)/Cl(-) betaine/GABA transporter) (Solute carrier family 6 member 12) |
| Target Name | sodium- and chloride-dependent betaine transporter |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000111181 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P48065 |
| Gene Card | SLC6A12 |
| Uniprot ID | P48065 |
| Pfam | PF00209 |
| In ASD | no |
| Allosteric Prediction | no (-0.398503316) |
| Ortholog in Animals | Alpaca_ SLC6A12 ( ortholog_one2one ) Dog_ SLC6A12 ( ortholog_one2one ) GuineaPig_ SLC6A12 ( ortholog_one2one ) Macaque_ SLC6A12 ( ortholog_one2one ) Mouse_ Slc6a12 ( ortholog_one2one ) Pig_ SLC6A12 ( ortholog_one2one ) Rat_ Slc6a12 ( ortholog_one2one ) |
| Ohnologs | SLC6A6, SLC6A11 |
| Paralogs | SLC6A20, SLC6A9, SLC6A2, SLC6A18, SLC6A7, SLC6A4, SLC6A16, SLC6A8, SLC6A5, SLC6A14, SLC6A6, SLC6A15, SLC6A13, SLC6A11, SLC6A19, SLC6A1, SLC6A17, SLC6A3 |
| Tissue | kidney, liver |
| Tissue Specificity | Liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs557881 |
| Subcellular location [CC] | Membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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