| Gene Information | |
|---|---|
| Gene Name | SRC |
| Organism | Homo sapiens (Human) |
| Gene Length | 536 |
| Protein Names | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) |
| Target Name | proto-oncogene tyrosine-protein kinase src |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000197122 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P12931 |
| Gene Card | SRC |
| Uniprot ID | P12931 |
| Pfam | PF07714; PF00017; PF00018 |
| In ASD | yes |
| Allosteric Prediction | yes (1.83821705) |
| Ortholog in Animals | Alpaca_ SRC ( ortholog_one2one ) Dog_ SRC ( ortholog_one2one ) GuineaPig_ SRC ( ortholog_one2one ) Macaque_ SRC ( ortholog_one2one ) Mouse_ Src ( ortholog_one2one ) Pig_ SRC ( ortholog_one2one ) Rat_ Src ( ortholog_one2one ) Rabbit_ SRC ( ortholog_one2one ) |
| Ohnologs | FGR, FYN, FRK, BLK, YES1, LCK |
| Paralogs | FGR, FRK, JAK3, BMX, FER, BTK, FES, BLK, JAK1, PTK2B, SYK, TYK2, LYN, ZAP70, TXK, TNK2, PTK2, SRMS, TEC, CSK, STYK1, YES1, LCK, JAK2, ITK, MATK, TNK1, HCK, ABL1, ABL2, FYN, PTK6 |
| Tissue | NA |
| Tissue Specificity | Expressed ubiquitously. Platelets, neurons and osteoclasts express 5-fold to 200-fold higher levels than most other tissues.; [Isoform 1]: Expressed in spleen and liver. {ECO:0000269|PubMed:8319227}.; [Isoform 2]: Expressed in brain. {ECO:0000269|PubMed:8319227}.; [Isoform 3]: Expressed in brain. {ECO:0000269|PubMed:8319227}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.009187(Mouse);0.007029(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1A07 (X-ray 2.20A ) 1A08 (X-ray 2.20A ) 1A09 (X-ray 2.00A ) 1A1A (X-ray 2.00A ) 1A1B (X-ray 2.20A ) 1A1C (X-ray 2.40A ) 1A1E (X-ray 2.20A ) 1FMK (X-ray 1.50A ) 1HCS (NMR - ) 1HCT (NMR - ) 1KSW (X-ray 2.80A ) 1O41 (X-ray 1.70A ) 1O42 (X-ray 1.70A ) 1O43 (X-ray 1.50A ) 1O44 (X-ray 1.70A ) 1O45 (X-ray 1.80A ) 1O46 (X-ray 2.00A ) 1O47 (X-ray 1.80A ) 1O48 (X-ray 1.55A ) 1O49 (X-ray 1.70A ) 1O4A (X-ray 1.50A ) 1O4B (X-ray 1.85A ) 1O4C (X-ray 1.80A ) 1O4D (X-ray 1.85A ) 1O4E (X-ray 2.00A ) 1O4F (X-ray 2.00A ) 1O4G (X-ray 1.55A ) 1O4H (X-ray 2.25A ) 1O4I (X-ray 1.75A ) 1O4J (X-ray 1.70A ) 1O4K (X-ray 1.57A ) 1O4L (X-ray 1.65A ) 1O4M (X-ray 1.60A ) 1O4N (X-ray 1.60A ) 1O4O (X-ray 1.70A ) 1O4P (X-ray 1.90A ) 1O4Q (X-ray 1.70A ) 1O4R (X-ray 1.50A ) 1SHD (X-ray 2.00A ) 1Y57 (X-ray 1.91A ) 1YI6 (X-ray 2.00A ) 1YOJ (X-ray 1.95A ) 1YOL (X-ray 2.30A ) 1YOM (X-ray 2.90A ) 2BDF (X-ray 2.10A ) 2BDJ (X-ray 2.50A ) 2H8H (X-ray 2.20A ) 2SRC (X-ray 1.50A ) 3VRO (X-ray 1.80A ) 3ZMP (X-ray 2.62A ) 3ZMQ (X-ray 3.30A ) 4F59 (X-ray 1.71A ) 4F5A (X-ray 1.80A ) 4F5B (X-ray 1.57A ) 4HXJ (X-ray 2.00A ) 4K11 (X-ray 2.30A ) 4MXO (X-ray 2.10A ) 4MXX (X-ray 2.60A ) 4MXY (X-ray 2.58A ) 4MXZ (X-ray 2.58A ) 6ATE (X-ray 2.40A ) 6C4S (X-ray 1.50A ) 6E6E (X-ray 2.15A ) 6EHJ (X-ray 2.10A ) 7NG7 (X-ray 1.50A ) 7OTE (X-ray 2.49A ) 7T1U (X-ray 2.65A ) |
| DBSNP | rs6018260 rs34881773 rs879255268 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:7525268}; Lipid-anchor {ECO:0000269|PubMed:22801373}. Mitochondrion inner membrane {ECO:0000269|PubMed:12615910}. Nucleus {ECO:0000269|PubMed:7853507}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:7525268}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19307596}. Cell junction, focal adhesion {ECO:0000269|PubMed:22801373}. Note=Localizes to focal adhesion sites following integrin engagement (PubMed:22801373). Localization to focal adhesion sites requires myristoylation and the SH3 domain (PubMed:7525268). Colocalizes with PDLIM4 at the perinuclear region, but not at focal adhesions (PubMed:19307596). {ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:22801373, ECO:0000269|PubMed:7525268}. |
| Mouse PG classification | LPG |
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