| Gene Information | |
|---|---|
| Gene Name | SQLE |
| Organism | Homo sapiens (Human) |
| Gene Length | 574 |
| Protein Names | Squalene monooxygenase (EC 1.14.14.17) (Squalene epoxidase) (SE) |
| Target Name | squalene monooxygenase |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000104549 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q14534 |
| Gene Card | SQLE |
| Uniprot ID | Q14534 |
| Pfam | PF08491 |
| In ASD | yes |
| Allosteric Prediction | yes (0.39792026) |
| Ortholog in Animals | Alpaca_ SQLE ( ortholog_one2one ) Dog_ SQLE ( ortholog_one2one ) GuineaPig_ SQLE ( ortholog_one2one ) Macaque_ SQLE ( ortholog_one2one ) Mouse_ Sqle ( ortholog_one2one ) Pig_ SQLE ( ortholog_one2one ) Rat_ Sqle ( ortholog_one2one ) Rabbit_ SQLE ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in liver (at protein level). {ECO:0000269|PubMed:30626872}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.005434(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6C6N (X-ray 2.30A ) 6C6P (X-ray 2.50A ) 6C6R (X-ray 3.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Microsome membrane {ECO:0000269|PubMed:26434806, ECO:0000269|PubMed:28972164, ECO:0000269|PubMed:30626872}; Peripheral membrane protein {ECO:0000269|PubMed:26434806, ECO:0000269|PubMed:28972164}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:26434806}; Peripheral membrane protein {ECO:0000269|PubMed:26434806, ECO:0000269|PubMed:28972164}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |