| Gene Information | |
|---|---|
| Gene Name | SPX |
| Organism | Homo sapiens (Human) |
| Gene Length | 116 |
| Protein Names | Spexin (NPQ) (Neuropeptide Q) (Spexin hormone) [Cleaved into: Spexin-1; Spexin-2 (NPQ 53-70)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000134548 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9BT56 |
| Gene Card | SPX |
| Uniprot ID | Q9BT56 |
| Pfam | PF15171 |
| In ASD | no |
| Allosteric Prediction | no (-0.800990333) |
| Ortholog in Animals | Alpaca_ SPX ( ortholog_one2one ) GuineaPig_ SPX ( ortholog_one2one ) Macaque_ SPX ( ortholog_one2one ) Mouse_ Spx ( ortholog_one2one ) Pig_ SPX ( ortholog_one2one ) Rat_ Spx ( ortholog_one2one ) Rabbit_ SPX ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | adipose.tissue |
| Tissue Specificity | Expressed in the type I glomic cells within the carotid body (at protein level). Expressed predominantly in pancreas, testis, kidney, brain and placenta. Expressed in submucosal layer of esophagus and stomach fundus. {ECO:0000269|PubMed:17284679, ECO:0000269|PubMed:19132080, ECO:0000269|PubMed:19193193, ECO:0000269|PubMed:23080164}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Secreted. Secreted, extracellular space. Cytoplasmic vesicle, secretory vesicle. Note=Secreted via the classical ER/Golgi-dependent pathway into the extracellular medium largely as a full-length protein without the signal peptide, and not as a hydrolyzed and amidated peptide (PubMed:19193193 and PubMed:17284679). Localized extracellularly surrounding the villous trophoblastic cells. Detected in the serum. |
| Mouse PG classification | NA |
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