| Gene Information | |
|---|---|
| Gene Name | PARP3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 533 |
| Protein Names | Protein mono-ADP-ribosyltransferase PARP3 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 3) (ARTD3) (DNA ADP-ribosyltransferase PARP3) (EC 2.4.2.-) (IRT1) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly [ADP-ribose] polymerase 3) (PARP-3) (hPARP-3) (Poly[ADP-ribose] synthase 3) (pADPRT-3) |
| Target Name | poly [adp-ribose] polymerase 3 |
| Target Type | Patented-recorded target |
| Gene Age | 680 ( ENSG00000041880 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9Y6F1 |
| Gene Card | PARP3 |
| Uniprot ID | Q9Y6F1 |
| Pfam | PF00644; PF02877; PF05406 |
| In ASD | no |
| Allosteric Prediction | yes (0.101704775) |
| Ortholog in Animals | Alpaca_ PARP3 ( ortholog_one2one ) Dog_ PARP3 ( ortholog_one2one ) GuineaPig_ PARP3 ( ortholog_one2one ) Macaque_ PARP3 ( ortholog_one2one ) Mouse_ Parp3 ( ortholog_one2one ) Pig_ PARP3 ( ortholog_one2one ) Rat_ Parp3 ( ortholog_one2one ) Rabbit_ PARP3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PARP2, PARP1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus. {ECO:0000269|PubMed:10329013}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2EOC (NMR - ) 3C49 (X-ray 2.80A ) 3C4H (X-ray 2.10A ) 3CE0 (X-ray 2.80A ) 3FHB (X-ray 2.30A ) 4GV0 (X-ray 1.90A ) 4GV2 (X-ray 1.80A ) 4GV4 (X-ray 1.80A ) 4L6Z (X-ray 2.00A ) 4L70 (X-ray 2.00A ) 4L7L (X-ray 2.10A ) 4L7N (X-ray 1.80A ) 4L7O (X-ray 2.00A ) 4L7P (X-ray 2.30A ) 4L7R (X-ray 2.20A ) 4L7U (X-ray 2.80A ) |
| DBSNP | rs34224216 rs28547534 rs323870 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:16924674}. Chromosome {ECO:0000269|PubMed:21270334, ECO:0000269|PubMed:27530147, ECO:0000269|PubMed:28447610}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10329013}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:10329013}. Note=Almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected (PubMed:16924674). In response to DNA damage, localizes to sites of double-strand break (PubMed:21270334, PubMed:28447610). Also localizes to single-strand breaks (PubMed:27530147). Preferentially localized to the daughter centriole (PubMed:10329013). {ECO:0000269|PubMed:10329013, ECO:0000269|PubMed:16924674, ECO:0000269|PubMed:21270334, ECO:0000269|PubMed:27530147, ECO:0000269|PubMed:28447610}. |
| Mouse PG classification | NA |
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