| Gene Information | |
|---|---|
| Gene Name | PRKAA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 552 |
| Protein Names | 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) |
| Target Name | 5'-amp-activated protein kinase |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000162409 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P54646 |
| Gene Card | PRKAA2 |
| Uniprot ID | P54646 |
| Pfam | PF16579; PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (1.412277354) |
| Ortholog in Animals | Alpaca_ PRKAA2 ( ortholog_one2one ) Dog_ PRKAA2 ( ortholog_one2one ) GuineaPig_ PRKAA2 ( ortholog_one2one ) Macaque_ PRKAA2 ( ortholog_one2one ) Mouse_ Prkaa2 ( ortholog_one2one ) Pig_ PRKAA2 ( ortholog_one2one ) Rat_ Prkaa2 ( ortholog_one2one ) Rabbit_ PRKAA2 ( ortholog_one2one ) |
| Ohnologs | PRKAA1 |
| Paralogs | TSSK6, SNRK, SIK2, SIK3, NIM1K, NUAK2, TSSK2, TSSK4, SIK1, BRSK2, NUAK1, BRSK1, HUNK, PRKAA1, TSSK1B, MELK, TSSK3 |
| Tissue | heart, kidney, skeletal.muscle |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.743621(Rat);0.212473(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2H6D (X-ray 1.85A ) 2LTU (NMR - ) 2YZA (X-ray 3.02A ) 3AQV (X-ray 2.08A ) 4CFE (X-ray 3.02A ) 4CFF (X-ray 3.92A ) 4ZHX (X-ray 2.99A ) 5EZV (X-ray 2.99A ) 5ISO (X-ray 2.63A ) 6B1U (X-ray 2.77A ) 6B2E (X-ray 3.80A ) 6BX6 (X-ray 2.90A ) 7MYJ (X-ray 2.95A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q8BRK8}. Nucleus {ECO:0000269|PubMed:15866171}. Note=In response to stress, recruited by p53/TP53 to specific promoters. {ECO:0000269|PubMed:15866171}. |
| Mouse PG classification | NA |
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