| Gene Information | |
|---|---|
| Gene Name | SET |
| Organism | Homo sapiens (Human) |
| Gene Length | 290 |
| Protein Names | Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 55 ( ENSG00000119335 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q01105 |
| Gene Card | SET |
| Uniprot ID | Q01105 |
| Pfam | PF00956 |
| In ASD | no |
| Allosteric Prediction | yes (0.117201858) |
| Ortholog in Animals | Alpaca_ SET ( ortholog_one2one ) Alpaca_ SET ( ortholog_one2many ) Rat_ RGD1563307 ( ortholog_one2one ) |
| Ohnologs | TSPYL5 |
| Paralogs | NAP1L4, NAP1L1, TSPYL6, TSPY9, TSPY2, TSPY8, TSPY3, TSPY4, TSPY10, TSPY1, NAP1L3, TSPYL2, NAP1L2, SETSIP, NAP1L5, TSPYL5, TSPYL4, TSPYL1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Low levels in quiescent cells during serum starvation, contact inhibition or differentiation. Highly expressed in Wilms' tumor. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2E50 (X-ray 2.30A ) 7MTO (X-ray 1.79A ) |
| DBSNP | rs1554776500 rs1564360978 rs1141138 |
| Subcellular location [CC] | Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus, nucleoplasm. Note=In the cytoplasm, found both in the cytosol and associated with the endoplasmic reticulum. The SET complex is associated with the endoplasmic reticulum. Following CTL attack and cleavage by GZMA, moves rapidly to the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus. Similar translocation to the nucleus is also observed for lymphocyte-activated killer cells after the addition of calcium. |
| Mouse PG classification | NA |
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