Gene Information
Gene NamePDE7A
OrganismHomo sapiens (Human)
Gene Length482
Protein NamesHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.53) (HCP1) (TM22)
Target Namecyclic nucleotide phosphodiesterase
Target TypeNA
Gene Age987 ( ENSG00000205268 )
Evolutionary StageOpisthokonta
AlphaFoldDBQ13946
Gene CardPDE7A
Uniprot IDQ13946
PfamPF00233
In ASDyes
Allosteric Predictionyes (0.943285315)
Ortholog in AnimalsAlpaca_ PDE7A ( ortholog_one2one )
Dog_ PDE7A ( ortholog_one2one )
GuineaPig_ PDE7A ( ortholog_one2one )
Macaque_ PDE7A ( ortholog_one2one )
Mouse_ Pde7a ( ortholog_one2one )
Pig_ PDE7A ( ortholog_one2one )
Rat_ Pde7a ( ortholog_one2one )
Rabbit_ PDE7A ( ortholog_one2one )
OhnologsPDE8A, PDE7B
ParalogsPDE8A, PDE4A, PDE4D, PDE4B, PDE6A, PDE2A, PDE6C, PDE8B, PDE1B, PDE9A, PDE10A, PDE1A, PDE3B, PDE1C, PDE11A, PDE5A, PDE3A, PDE7B, PDE6B, PDE4C
TissueNA
Tissue Specificity[Isoform PDE7A1]: Found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart (PubMed:9195912). It is expressed as well in two T-cell lines (PubMed:9195912). {ECO:0000269|PubMed:9195912}.;
[Isoform PDE7A2]: Found abundantly in skeletal muscle and at low levels in heart. {ECO:0000269|PubMed:9195912}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1ZKL  (X-ray  1.67A  )  3G3N  (X-ray  2.40A  )  4PM0  (X-ray  2.10A  )  4Y2B  (X-ray  2.20A  ) 
DBSNP rs11557049 
Subcellular location [CC][Isoform PDE7A1]: Cytoplasm, cytosol {ECO:0000269|PubMed:9195912}. Note=PDE7A1 (57 kDa) is located mostly to soluble cellular fractions. {ECO:0000269|PubMed:9195912}.;
[Isoform PDE7A2]: Cytoplasm {ECO:0000269|PubMed:9195912}. Note=PDE7A2 (50 kDa) is located to particulate cellular fractions. {ECO:0000269|PubMed:9195912}.
Mouse PG classificationNA
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