| Gene Information | |
|---|---|
| Gene Name | PCNA |
| Organism | Homo sapiens (Human) |
| Gene Length | 261 |
| Protein Names | Proliferating cell nuclear antigen (PCNA) (Cyclin) |
| Target Name | proliferating cell nuclear antigen |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000132646 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | P12004 |
| Gene Card | PCNA |
| Uniprot ID | P12004 |
| Pfam | PF02747; PF00705 |
| In ASD | no |
| Allosteric Prediction | yes (0.41509019) |
| Ortholog in Animals | Alpaca_ PCNA ( ortholog_one2one ) Dog_ PCNA ( ortholog_one2one ) GuineaPig_ PCNA ( ortholog_one2one ) Macaque_ PCNA ( ortholog_one2one ) Mouse_ Pcna ( ortholog_one2one ) Rat_ Pcna ( ortholog_one2one ) Rabbit_ PCNA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.050492(Chimpanzee);0.061387(Mouse);0.035555(Rat);0.051042(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1AXC (X-ray 2.60A ) 1U76 (X-ray 2.60A ) 1U7B (X-ray 1.88A ) 1UL1 (X-ray 2.90A ) 1VYJ (X-ray 2.80A ) 1VYM (X-ray 2.30A ) 1W60 (X-ray 3.15A ) 2ZVK (X-ray 2.70A ) 2ZVL (X-ray 2.50A ) 2ZVM (X-ray 2.30A ) 3JA9 (EM 22.00A ) 3P87 (X-ray 2.99A ) 3TBL (X-ray 2.90A ) 3VKX (X-ray 2.10A ) 3WGW (X-ray 2.80A ) 4D2G (X-ray 2.65A ) 4RJF (X-ray 2.01A ) 4ZTD (X-ray 2.20A ) 5E0T (X-ray 2.67A ) 5E0U (X-ray 1.93A ) 5E0V (X-ray 2.07A ) 5IY4 (X-ray 2.94A ) 5MAV (X-ray 2.58A ) 5MLO (X-ray 1.96A ) 5MLW (X-ray 2.45A ) 5MOM (X-ray 2.27A ) 5YCO (X-ray 2.20A ) 5YD8 (X-ray 2.30A ) 6CBI (X-ray 2.75A ) 6EHT (X-ray 3.20A ) 6FCM (X-ray 2.80A ) 6FCN (X-ray 3.22A ) 6GIS (X-ray 2.82A ) 6GWS (X-ray 2.90A ) 6HVO (X-ray 2.10A ) 6K3A (X-ray 2.30A ) 6QC0 (X-ray 3.50A ) 6QCG (X-ray 3.40A ) 6S1M (EM 4.27A ) 6S1N (EM 4.86A ) 6S1O (EM 8.10A ) 6TNY (EM 3.08A ) 6TNZ (EM 4.05A ) 6VVO (EM 3.40A ) 7EFA (X-ray 2.70A ) 7KQ0 (X-ray 2.40A ) 7KQ1 (X-ray 3.30A ) 7M5L (X-ray 3.00A ) 7M5M (X-ray 3.00A ) 7M5N (X-ray 3.11A ) 7NV0 (EM 3.40A ) 7NV1 (EM 6.40A ) |
| DBSNP | rs369958038 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:24115439, ECO:0000269|PubMed:24939902}. Note=Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase (PubMed:15543136). Co-localizes with SMARCA5/SNF2H and BAZ1B/WSTF at replication foci during S phase (PubMed:15543136). Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. {ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:24939902}. |
| Mouse PG classification | NA |
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