| Gene Information | |
|---|---|
| Gene Name | SCUBE3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 993 |
| Protein Names | Signal peptide, CUB and EGF-like domain-containing protein 3 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000146197 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8IX30 |
| Gene Card | SCUBE3 |
| Uniprot ID | Q8IX30 |
| Pfam | PF12662; PF00431; PF12947; PF07645; PF07699 |
| In ASD | no |
| Allosteric Prediction | no (-0.555699126) |
| Ortholog in Animals | Alpaca_ SCUBE3 ( ortholog_one2one ) Dog_ SCUBE3 ( ortholog_one2one ) GuineaPig_ SCUBE3 ( ortholog_one2one ) Macaque_ SCUBE3 ( ortholog_one2one ) Mouse_ Scube3 ( ortholog_one2one ) Pig_ SCUBE3 ( ortholog_one2one ) Rat_ Scube3 ( ortholog_one2one ) Rabbit_ SCUBE3 ( ortholog_one2one ) |
| Ohnologs | SCUBE1, SCUBE2 |
| Paralogs | SCUBE1, SCUBE2 |
| Tissue | thyroid, aorta, tibial.artery |
| Tissue Specificity | Highly expressed in osteoblasts. In normal lung, mainly expressed in bronchial epithelial cells. Tends to be up-regulated in lung cancer cells. {ECO:0000269|PubMed:15234972, ECO:0000269|PubMed:21441952}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1783419625 rs1783620400 rs3800381 rs751478115 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:15234972, ECO:0000269|PubMed:33308444}. Cell surface {ECO:0000269|PubMed:15234972, ECO:0000269|PubMed:33308444}. |
| Mouse PG classification | NA |
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