| Gene Information | |
|---|---|
| Gene Name | SPP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 441 |
| Protein Names | Sphingosine-1-phosphate phosphatase 1 (SPPase1) (Spp1) (hSPP1) (hSPPase1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1) (Sphingosine-1-phosphate phosphohydrolase 1) (SPP-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000118785 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9BX95 |
| Gene Card | SGPP1 |
| Uniprot ID | Q9BX95 |
| Pfam | PF01569 |
| In ASD | no |
| Allosteric Prediction | yes (0.842295595) |
| Ortholog in Animals | Alpaca_ SPP1 ( ortholog_one2one ) Dog_ SPP1 ( ortholog_one2one ) GuineaPig_ SPP1 ( ortholog_one2one ) Macaque_ SPP1 ( ortholog_one2one ) Mouse_ Spp1 ( ortholog_one2one ) Pig_ SPP1 ( ortholog_one2one ) Rat_ Spp1 ( ortholog_one2one ) Rabbit_ SPP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous, with the strongest level in placenta and kidney. {ECO:0000269|PubMed:12815058}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12815058}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9JI99}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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