| Gene Information | |
|---|---|
| Gene Name | SPN |
| Organism | Homo sapiens (Human) |
| Gene Length | 400 |
| Protein Names | Leukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000197471 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P16150 |
| Gene Card | SPN |
| Uniprot ID | P16150 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.341512135) |
| Ortholog in Animals | GuineaPig_ SPN ( ortholog_one2one ) Macaque_ SPN ( ortholog_one2one ) Mouse_ Spn ( ortholog_one2one ) Pig_ SPN ( ortholog_one2one ) Rat_ Spn ( ortholog_one2many ) Rat_ MGC112692 ( ortholog_one2many ) Rat_ AABR07035501.1 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2229653 rs2229654 |
| Subcellular location [CC] | Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, microvillus {ECO:0000250|UniProtKB:P13838}. Cell projection, uropodium {ECO:0000250|UniProtKB:P15702}. Note=Localizes to the uropodium and microvilli via its interaction with ERM proteins (EZR, RDX and MSN). {ECO:0000250|UniProtKB:P13838, ECO:0000250|UniProtKB:P15702}.; [CD43 cytoplasmic tail]: Nucleus {ECO:0000269|PubMed:15003504}. Nucleus, PML body {ECO:0000250|UniProtKB:P15702}. Note=The sumoylated form localizes to the PML body. {ECO:0000250|UniProtKB:P15702}. |
| Mouse PG classification | NA |
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