| Gene Information | |
|---|---|
| Gene Name | SPN |
| Organism | Homo sapiens (Human) |
| Gene Length | 565 |
| Protein Names | Deformed epidermal autoregulatory factor 1 homolog (Nuclear DEAF-1-related transcriptional regulator) (NUDR) (Suppressin) (Zinc finger MYND domain-containing protein 5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000197471 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | O75398 |
| Gene Card | DEAF1 |
| Uniprot ID | O75398 |
| Pfam | PF01342; PF01753 |
| In ASD | no |
| Allosteric Prediction | no (-0.341512135) |
| Ortholog in Animals | GuineaPig_ SPN ( ortholog_one2one ) Macaque_ SPN ( ortholog_one2one ) Mouse_ Spn ( ortholog_one2one ) Pig_ SPN ( ortholog_one2one ) Rat_ Spn ( ortholog_one2many ) Rat_ MGC112692 ( ortholog_one2many ) Rat_ AABR07035501.1 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in various tissues and cells such as in peripheral mononuclear cells and hormone-secreting pituitary cells. Expression in pancreatic lymph nodes of patients with type 1 diabetes is 20 times higher than in healthy controls. Highly expressed in fetal and adult brain. {ECO:0000269|PubMed:19668219, ECO:0000269|PubMed:24726472}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2JW6 (NMR - ) 4A24 (NMR - ) 5UWW (X-ray 2.15A ) |
| DBSNP | rs751727919 rs1127312 rs587777408 rs587777623 rs587777406 rs587777409 rs587777407 rs34114147 |
| Subcellular location [CC] | [Isoform 1]: Nucleus. Cytoplasm. Note=Cytoplasmic in non-mucinous colorectal carcinoma. When expressed alone, localized almost exclusively in the nucleus but, when expressed with isoform 4, nuclear expression decreases to 32% and cytoplasmic expression increases by 270%.; [Isoform 2]: Secreted. Note=Secreted in some cell types.; [Isoform 3]: Secreted. Note=Secreted in some cell types.; [Isoform 4]: Cytoplasm. Nucleus. Note=When expressed alone, localizes mainly in the cytoplasm but, when expressed with isoform 1, nuclear localization is enhanced. |
| Mouse PG classification | NA |
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