| Gene Information | |
|---|---|
| Gene Name | SPIRE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 756 |
| Protein Names | Protein spire homolog 1 (Spir-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000134278 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q08AE8 |
| Gene Card | SPIRE1 |
| Uniprot ID | Q08AE8 |
| Pfam | PF16474 |
| In ASD | no |
| Allosteric Prediction | no (-0.712427892) |
| Ortholog in Animals | Alpaca_ SPIRE1 ( ortholog_one2one ) Dog_ SPIRE1 ( ortholog_one2one ) GuineaPig_ SPIRE1 ( ortholog_one2one ) Macaque_ SPIRE1 ( ortholog_one2one ) Mouse_ Spire1 ( ortholog_one2one ) Pig_ SPIRE1 ( ortholog_one2one ) Rat_ Spire1 ( ortholog_one2one ) Rabbit_ SPIRE1 ( ortholog_one2one ) |
| Ohnologs | SPIRE2 |
| Paralogs | SPIRE2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2YLE (X-ray 1.80A ) 2YLF (X-ray 2.05A ) 3R7G (X-ray 2.20A ) 3RBW (X-ray 3.20A ) |
| DBSNP | rs1785296 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11747823}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11747823}. Cell membrane {ECO:0000269|PubMed:11747823}; Peripheral membrane protein {ECO:0000269|PubMed:11747823}; Cytoplasmic side {ECO:0000269|PubMed:11747823}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q52KF3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q52KF3}; Cytoplasmic side {ECO:0000250|UniProtKB:Q52KF3}. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity). Punctate spots in perinuclear region and cytoplasm, colocalized with Rab11 (By similarity). {ECO:0000250|UniProtKB:Q52KF3}. |
| Mouse PG classification | NA |
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