| Gene Information | |
|---|---|
| Gene Name | CASP14 |
| Organism | Homo sapiens (Human) |
| Gene Length | 242 |
| Protein Names | Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000105141 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P31944 |
| Gene Card | CASP14 |
| Uniprot ID | P31944 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.065146117) |
| Ortholog in Animals | Alpaca_ CASP14 ( ortholog_one2one ) Dog_ CASP14 ( ortholog_one2one ) GuineaPig_ CASP14 ( ortholog_one2one ) Macaque_ CASP14 ( ortholog_one2one ) Mouse_ Casp14 ( ortholog_one2one ) Pig_ CASP14 ( ortholog_one2one ) Rat_ Casp14 ( ortholog_one2one ) Rabbit_ CASP14 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PYCARD, CASP8, CASP2, CASP6, CFLAR, CASP10, CARD18, CASP9, CASP1, CARD16, CASP5, CASP4, CASP3, CASP7, PYDC1, CASP12 |
| Tissue | skin, zone.of.skin, lower.leg.skin, suprapubic.skin |
| Tissue Specificity | Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels (PubMed:11175259). The p17/10 mature form is expressed in epidermis stratum corneum, the p20/p8 intermediate form in epidermis upper granular cells of the stratum granulosum (PubMed:22825846). {ECO:0000269|PubMed:11175259, ECO:0000269|PubMed:15556625, ECO:0000269|PubMed:22825846}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11175259, ECO:0000269|PubMed:12200134, ECO:0000269|PubMed:22825846}. Nucleus {ECO:0000269|PubMed:11175259}. |
| Mouse PG classification | NA |
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