| Gene Information | |
|---|---|
| Gene Name | SPIB |
| Organism | Homo sapiens (Human) |
| Gene Length | 262 |
| Protein Names | Transcription factor Spi-B |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000269404 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q01892 |
| Gene Card | SPIB |
| Uniprot ID | Q01892 |
| Pfam | PF00178 |
| In ASD | no |
| Allosteric Prediction | no (-0.985010219) |
| Ortholog in Animals | Dog_ MYBPC2 ( ortholog_one2one ) GuineaPig_ SPIB ( ortholog_one2one ) Macaque_ SPIB ( ortholog_one2one ) Mouse_ Spib ( ortholog_one2one ) Pig_ SPIB ( ortholog_one2one ) Rat_ Spib ( ortholog_one2one ) Rabbit_ SPIB ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ELK1, ETV6, ERG, ERF, ETV4, ETV7, ELF4, ELF3, EHF, ETV2, ETV3L, ETS2, FLI1, GABPA, ETV5, ETV1, ELF5, ETV3, ELK3, ETS1, ELF2, SPI1, ELK4, ELF1, FEV, SPIC, ERFL, SPDEF |
| Tissue | tonsil, appendix |
| Tissue Specificity | Expressed in plasmacytoid dendritic cells (pDCs) and B-cells, not expressed in T-cells or granulocytes. May also be enriched in stem cell populations of the liver. {ECO:0000269|PubMed:11841448, ECO:0000269|PubMed:12393575}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11546996 |
| Subcellular location [CC] | [Isoform 1]: Nucleus {ECO:0000269|PubMed:12393575}.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:12393575}. |
| Mouse PG classification | NA |
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