| Gene Information | |
|---|---|
| Gene Name | SPI1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 270 |
| Protein Names | Transcription factor PU.1 (31 kDa-transforming protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000066336 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P17947 |
| Gene Card | SPI1 |
| Uniprot ID | P17947 |
| Pfam | PF00178 |
| In ASD | no |
| Allosteric Prediction | yes (0.077374627) |
| Ortholog in Animals | Alpaca_ SPI1 ( ortholog_one2one ) Dog_ SPI1 ( ortholog_one2one ) GuineaPig_ SPI1 ( ortholog_one2one ) Macaque_ SPI1 ( ortholog_one2one ) Mouse_ Spi1 ( ortholog_one2one ) Pig_ SPI1 ( ortholog_one2one ) Rat_ Spi1 ( ortholog_one2one ) |
| Ohnologs | SPIC |
| Paralogs | ELK1, ETV6, ERG, ERF, ETV4, ETV7, ELF4, ELF3, EHF, ETV2, ETV3L, ETS2, FLI1, GABPA, ETV5, ETV1, ELF5, ETV3, ELK3, ETS1, ELF2, ELK4, ELF1, SPIB, FEV, SPIC, ERFL, SPDEF |
| Tissue | appendix, bone.marrow, dura.mater, epididymis, left.ventricle, lung, lymph.node, spleen |
| Tissue Specificity | In the bone marrow, concentrated in hematopoietic stem cell, lymphoid progenitor, myeloid lineage (granulocyte macrophage progenitors, classical dendritic cells, monocytes) and B-cell clusters. Among B-cells, predominantly expressed in pre-B1 cells (PubMed:33951726). Expressed in germinal center B-cells (PubMed:23166356). {ECO:0000269|PubMed:23166356, ECO:0000269|PubMed:33951726}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2095906547 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237, ECO:0000269|PubMed:33951726}. |
| Mouse PG classification | NA |
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