| Gene Information | |
|---|---|
| Gene Name | PDE4B |
| Organism | Homo sapiens (Human) |
| Gene Length | 736 |
| Protein Names | cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) |
| Target Name | camp-specific 3',5'-cyclic phosphodiesterase 4b |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000184588 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q07343 |
| Gene Card | PDE4B |
| Uniprot ID | Q07343 |
| Pfam | PF18100; PF00233 |
| In ASD | no |
| Allosteric Prediction | yes (1.249642392) |
| Ortholog in Animals | Alpaca_ PDE4B ( ortholog_one2one ) Dog_ PDE4B ( ortholog_one2one ) GuineaPig_ PDE4B ( ortholog_one2one ) Macaque_ PDE4B ( ortholog_one2one ) Mouse_ Pde4b ( ortholog_one2one ) Pig_ PDE4B ( ortholog_one2one ) Rat_ Pde4b ( ortholog_one2one ) Rabbit_ PDE4B ( ortholog_one2one ) |
| Ohnologs | PDE4A, PDE4C, PDE4D |
| Paralogs | PDE8A, PDE4A, PDE4D, PDE6A, PDE2A, PDE6C, PDE8B, PDE1B, PDE9A, PDE10A, PDE1A, PDE7A, PDE3B, PDE1C, PDE11A, PDE5A, PDE3A, PDE7B, PDE6B, PDE4C |
| Tissue | NA |
| Tissue Specificity | Expressed in brain, heart, lung and skeletal muscle (PubMed:17519386). Expressed in white blood cells (PubMed:8392015). {ECO:0000269|PubMed:17519386, ECO:0000269|PubMed:8392015}.; [Isoform PDE4B5]: Brain-specific isoform. {ECO:0000269|PubMed:17519386}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1F0J (X-ray 1.77A ) 1RO6 (X-ray 2.00A ) 1RO9 (X-ray 2.13A ) 1ROR (X-ray 2.00A ) 1TB5 (X-ray 2.15A ) 1XLX (X-ray 2.19A ) 1XLZ (X-ray 2.06A ) 1XM4 (X-ray 2.31A ) 1XM6 (X-ray 1.92A ) 1XMU (X-ray 2.30A ) 1XMY (X-ray 2.40A ) 1XN0 (X-ray 2.31A ) 1XOS (X-ray 2.28A ) 1XOT (X-ray 2.34A ) 1Y2H (X-ray 2.40A ) 1Y2J (X-ray 2.55A ) 2CHM (X-ray 1.60A ) 2QYL (X-ray 1.95A ) 3D3P (X-ray 1.75A ) 3FRG (X-ray 1.70A ) 3G45 (X-ray 2.63A ) 3GWT (X-ray 1.75A ) 3HC8 (X-ray 1.79A ) 3HDZ (X-ray 1.80A ) 3HMV (X-ray 2.23A ) 3KKT (X-ray 2.48A ) 3LY2 (X-ray 2.60A ) 3O0J (X-ray 1.95A ) 3O56 (X-ray 2.42A ) 3O57 (X-ray 2.00A ) 3W5E (X-ray 2.30A ) 3WD9 (X-ray 2.50A ) 4KP6 (X-ray 1.50A ) 4MYQ (X-ray 1.90A ) 4NW7 (X-ray 2.15A ) 4WZI (X-ray 2.58A ) 4X0F (X-ray 3.22A ) 5K6J (X-ray 1.86A ) 5LAQ (X-ray 2.40A ) 5OHJ (X-ray 1.60A ) 6BOJ (X-ray 1.70A ) |
| DBSNP | rs2227297 |
| Subcellular location [CC] | [Isoform PDE4B5]: Cytoplasm {ECO:0000269|PubMed:17519386}. Cell membrane {ECO:0000269|PubMed:17519386}. |
| Mouse PG classification | NA |
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