| Gene Information | |
|---|---|
| Gene Name | SPG21 |
| Organism | Homo sapiens (Human) |
| Gene Length | 308 |
| Protein Names | Maspardin (Acid cluster protein 33) (Spastic paraplegia 21 autosomal recessive Mast syndrome protein) (Spastic paraplegia 21 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000090487 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NZD8 |
| Gene Card | SPG21 |
| Uniprot ID | Q9NZD8 |
| Pfam | PF00561 |
| In ASD | no |
| Allosteric Prediction | no (-0.650230057) |
| Ortholog in Animals | Alpaca_ SPG21 ( ortholog_one2one ) Dog_ SPG21 ( ortholog_one2one ) GuineaPig_ SPG21 ( ortholog_one2one ) Macaque_ SPG21 ( ortholog_one2one ) Mouse_ Spg21 ( ortholog_one2one ) Pig_ SPG21 ( ortholog_one2one ) Rat_ Spg21 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in J.CaM1.6, HuT 78 and HeLa cell lines (at protein level). {ECO:0000269|PubMed:11113139}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:11113139}. Membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Endosome membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Note=Partially localized in the cytosol but also accumulated on an intracellular vesicular compartment. Colocalizes with CD4 on endosomal/trans-Golgi network. |
| Mouse PG classification | NA |
| click here to return to the previous page | |