| Gene Information | |
|---|---|
| Gene Name | PDE6A |
| Organism | Homo sapiens (Human) |
| Gene Length | 860 |
| Protein Names | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (GMP-PDE alpha) (EC 3.1.4.35) (PDE V-B1) |
| Target Name | cyclic nucleotide phosphodiesterase |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000132915 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P16499 |
| Gene Card | PDE6A |
| Uniprot ID | P16499 |
| Pfam | PF01590; PF00233 |
| In ASD | no |
| Allosteric Prediction | yes (0.819464786) |
| Ortholog in Animals | Alpaca_ PDE6A ( ortholog_one2one ) Dog_ PDE6A ( ortholog_one2one ) GuineaPig_ PDE6A ( ortholog_one2one ) Macaque_ PDE6A ( ortholog_one2one ) Mouse_ Pde6a ( ortholog_one2one ) Pig_ PDE6A ( ortholog_one2one ) Rat_ Pde6a ( ortholog_one2one ) Rabbit_ PDE6A ( ortholog_one2one ) |
| Ohnologs | PDE6C, PDE6B, PDE5A |
| Paralogs | PDE8A, PDE4A, PDE4D, PDE4B, PDE2A, PDE6C, PDE8B, PDE1B, PDE9A, PDE10A, PDE1A, PDE7A, PDE3B, PDE1C, PDE11A, PDE5A, PDE3A, PDE7B, PDE6B, PDE4C |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs750539462 rs141252097 rs35431421 rs10057110 rs145608358 rs114973968 rs121918577 rs61732059 rs17711594 rs139444207 rs755527251 rs780450680 rs138315990 |
| Subcellular location [CC] | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:20940301}. |
| Mouse PG classification | HPG |
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