| Gene Information | |
|---|---|
| Gene Name | SPRED2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 418 |
| Protein Names | Sprouty-related, EVH1 domain-containing protein 2 (Spred-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000198369 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q7Z698 |
| Gene Card | SPRED2 |
| Uniprot ID | Q7Z698 |
| Pfam | PF05210; PF00568 |
| In ASD | no |
| Allosteric Prediction | no (-0.317608465) |
| Ortholog in Animals | Alpaca_ SPRED2 ( ortholog_one2one ) Dog_ SPRED2 ( ortholog_one2one ) GuineaPig_ SPRED2 ( ortholog_one2one ) Macaque_ SPRED2 ( ortholog_one2one ) Mouse_ Spred2 ( ortholog_one2one ) Pig_ SPRED2 ( ortholog_one2one ) Rat_ Spred2 ( ortholog_one2one ) Rabbit_ SPRED2 ( ortholog_one2one ) |
| Ohnologs | SPRED1 |
| Paralogs | SPRED3, SPRED1, VASP, ENAH, EVL |
| Tissue | NA |
| Tissue Specificity | Expressed in liver, skin, small intestine, salivary gland and prostate. {ECO:0000269|PubMed:15580519}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2JP2 (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:34626534}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q924S7}; Cytoplasmic side {ECO:0000250|UniProtKB:Q924S7}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:15580519}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:15580519}. Note=Detected in the cytoplasm of the stratum spinosum cells, where it is associated with cytoplasmic vesicles that are supposed to be secretory granules. {ECO:0000269|PubMed:15580519}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |