| Gene Information | |
|---|---|
| Gene Name | SPEG |
| Organism | Homo sapiens (Human) |
| Gene Length | 3267 |
| Protein Names | Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000072195 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | NA |
| Gene Card | SPEG |
| Uniprot ID | Q15772 |
| Pfam | PF07679; PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.000898023) |
| Ortholog in Animals | Alpaca_ SPEG ( ortholog_one2one ) Dog_ SPEG ( ortholog_one2one ) Macaque_ SPEG ( ortholog_one2one ) Mouse_ Speg ( ortholog_one2one ) Rat_ Speg ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | OBSCN, PALLD, MYPN, HMCN1, IGFN1, CCDC141, ALPK3, SPEGNB, MYOT |
| Tissue | heart, sigmoid.colon |
| Tissue Specificity | Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly expressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of atherosclerosis. {ECO:0000269|PubMed:15185077, ECO:0000269|PubMed:8663449}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.025(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1U2H (X-ray 0.96A ) |
| DBSNP | rs55821435 rs34398769 rs34861443 rs56334571 rs55670811 rs757589345 rs55916864 rs34994343 rs55646900 rs762000831 rs10755037 rs13026308 rs566841339 rs587777676 rs12464085 |
| Subcellular location [CC] | [Isoform 3]: Nucleus. |
| Mouse PG classification | LPG |
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