| Gene Information | |
|---|---|
| Gene Name | PCSK4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 755 |
| Protein Names | Proprotein convertase subtilisin/kexin type 4 (EC 3.4.21.-) (Proprotein convertase 4) (PC4) |
| Target Name | proprotein convertase subtilisin/kexin type 4 |
| Target Type | Literature-reported target |
| Gene Age | 1488 ( ENSG00000115257 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q6UW60 |
| Gene Card | PCSK4 |
| Uniprot ID | Q6UW60 |
| Pfam | PF01483; PF00082; PF16470 |
| In ASD | no |
| Allosteric Prediction | no (-0.999741623) |
| Ortholog in Animals | Alpaca_ PCSK4 ( ortholog_one2one ) Dog_ PCSK4 ( ortholog_one2one ) GuineaPig_ PCSK4 ( ortholog_one2one ) Macaque_ PCSK4 ( ortholog_one2one ) Mouse_ Pcsk4 ( ortholog_one2one ) Pig_ PCSK4 ( ortholog_one2one ) Rat_ Pcsk4 ( ortholog_one2one ) |
| Ohnologs | PCSK6, FURIN, PCSK1 |
| Paralogs | PCSK1, TPP2, PCSK6, MBTPS1, PCSK7, PCSK5, PCSK9, FURIN, PCSK2 |
| Tissue | testis |
| Tissue Specificity | Placenta. {ECO:0000269|PubMed:16040806}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs36123574 |
| Subcellular location [CC] | Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:P29121}. |
| Mouse PG classification | NA |
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