| Gene Information | |
|---|---|
| Gene Name | PRKCZ |
| Organism | Homo sapiens (Human) |
| Gene Length | 592 |
| Protein Names | Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) |
| Target Name | pkc-zeta messenger rna |
| Target Type | Literature-reported target |
| Gene Age | 680 ( ENSG00000067606 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q05513 |
| Gene Card | PRKCZ |
| Uniprot ID | Q05513 |
| Pfam | PF00130; PF00564; PF00069; PF00433 |
| In ASD | yes |
| Allosteric Prediction | yes (1.488259695) |
| Ortholog in Animals | Dog_ PRKCZ ( ortholog_one2one ) GuineaPig_ PRKCZ ( ortholog_one2one ) Macaque_ PRKCZ ( ortholog_one2one ) Mouse_ Prkcz ( ortholog_one2one ) Pig_ PRKCZ ( ortholog_one2one ) Rat_ Prkcz ( ortholog_one2one ) |
| Ohnologs | PRKCI |
| Paralogs | PKN3, PKN1, PRKCE, PRKCH, PKN2, PRKCG, PRKCA, PRKCB, PRKCI |
| Tissue | NA |
| Tissue Specificity | Expressed in brain, and to a lesser extent in lung, kidney and testis. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002272(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs35271800 rs56017162 rs376894109 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17313651, ECO:0000269|PubMed:9566925}. Endosome {ECO:0000269|PubMed:9566925}. Cell junction {ECO:0000269|PubMed:7597083}. Membrane {ECO:0000250|UniProtKB:P09217}; Peripheral membrane protein {ECO:0000305}. Note=In the retina, localizes in the terminals of the rod bipolar cells (By similarity). Associates with endosomes (PubMed:9566925). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction (PubMed:7597083). Colocalizes with VAMP2 and WDFY2 in intracellular vesicles (PubMed:17313651). Transiently translocates to the membrane of CA1 hippocampal cells in response to the induction of long term potentiation (By similarity). {ECO:0000250|UniProtKB:P09217, ECO:0000269|PubMed:17313651, ECO:0000269|PubMed:7597083, ECO:0000269|PubMed:9566925}.; [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:P09217}. |
| Mouse PG classification | NA |
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