Gene Information
Gene NameABCC6
OrganismHomo sapiens (Human)
Gene Length1503
Protein NamesATP-binding cassette sub-family C member 6 (EC 7.6.2.-) (EC 7.6.2.3) (Anthracycline resistance-associated protein) (Multi-specific organic anion transporter E) (MOAT-E) (Multidrug resistance-associated protein 6)
Target Namemultidrug resistance-associated protein 6
Target TypeNA
Gene Age424 ( ENSG00000091262 )
3 ( ENSG00000275331 )
Evolutionary StageMammalia
AlphaFoldDBO95255
Gene CardABCC6
Uniprot IDO95255
PfamPF00664; PF00005
In ASDno
Allosteric Predictionyes (0.111859476)
Ortholog in AnimalsDog_ ABCC6 ( ortholog_one2one )
GuineaPig_ ABCC6 ( ortholog_one2one )
Macaque_ ABCC6 ( ortholog_one2one )
Mouse_ Abcc6 ( ortholog_one2one )
Pig_ ABCC6 ( ortholog_one2one )
Rat_ Abcc6 ( ortholog_one2one )
Rabbit_ ABCC6 ( ortholog_one2one )
OhnologsABCC3
ParalogsABCC1, ABCC8, ABCC3, ABCC10, ABCC9, ABCC5, ABCC4, ABCC12, CFTR, ABCC2, ABCC11
Tissueduodenum, kidney, liver, small.intestine
Tissue SpecificityExpressed in kidney and liver. Very low expression in other tissues.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6BZR  (X-ray  2.80A  )  6BZS  (X-ray  2.30A  )  6NLO  (X-ray  2.85A  )  6P7F  (X-ray  2.85A  ) 
DBSNP rs1555523872  rs1555523855  rs1235912910  rs72657696  rs777566074  rs557180313  rs72664225  rs2856597  rs957828732  rs879956688  rs72653753  rs2606921  rs72657697  rs72657698  rs879274205  rs78678589  rs72657699  rs72653758  rs72653759  rs72653760  rs72653761  rs72653762  rs72653763  rs72653764  rs9930886  rs768869262  rs772434460  rs72653766  rs67996819  rs72653767  rs72653769  rs72653770  rs59157279  rs72653772  rs72653773  rs72653774  rs66864704  rs537233133  rs72653776  rs72653777  rs768271196  rs12931472  rs8058694  rs72653780  rs4341770  rs67470842  rs72653782  rs72653783  rs72653784  rs1555513103  rs58073789  rs72653785  rs59593133  rs72653786  rs72653787  rs72653788  rs67561842  rs72653789  rs72653790  rs72653794  rs72653793  rs72653795  rs72653796  rs72653797  rs1355752953  rs6416668  rs72653800  rs72653801  rs61340537  rs1555510407  rs72657689  rs72657700  rs72657692  rs72664230  rs72657694  rs41278174  rs60707953  rs63749794  rs63750427  rs63750987  rs63750987  rs63750459  rs63750473  rs60791294  rs60791294  rs28939701  rs63750146  rs63750457  rs63750607  rs63751215  rs63751001  rs63750125  rs63750402  rs63749796  rs72657701  rs2238472  rs63751325  rs63750494  rs63749856  rs63750410  rs63751086  rs63750759  rs63749823  rs63750414  rs63750414  rs28939702  rs63750622  rs63750622  rs63751112  rs63751111  rs63750018  rs63750428  rs58695352  rs63751241  rs387906859  rs63750295  rs1462269230  rs72547524 
Subcellular location [CC][Isoform 1]: Basolateral cell membrane {ECO:0000269|PubMed:12901863, ECO:0000269|PubMed:23625951};
Multi-pass membrane protein {ECO:0000255}.;
[Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23912081};
Single-pass membrane protein {ECO:0000255}.
Mouse PG classificationHPG
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