| Gene Information | |
|---|---|
| Gene Name | SRCIN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1183 |
| Protein Names | SRC kinase signaling inhibitor 1 (SNAP-25-interacting protein) (SNIP) (p130Cas-associated protein) (p140Cap) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 3 ( ENSG00000273608 ) 950 ( ENSG00000277363 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9C0H9 |
| Gene Card | SRCIN1 |
| Uniprot ID | Q9C0H9 |
| Pfam | PF03915 |
| In ASD | no |
| Allosteric Prediction | no (-0.334983986) |
| Ortholog in Animals | Alpaca_ SRCIN1 ( ortholog_one2one ) Dog_ SRCIN1 ( ortholog_one2one ) GuineaPig_ SRCIN1 ( ortholog_one2one ) Macaque_ SRCIN1 ( ortholog_one2one ) Mouse_ Srcin1 ( ortholog_one2one ) Pig_ SRCIN1 ( ortholog_one2one ) Rat_ Srcin1 ( ortholog_one2one ) Rabbit_ SRCIN1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KIAA1217 |
| Tissue | cerebral.cortex |
| Tissue Specificity | Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue. {ECO:0000269|PubMed:18475297}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q9QXY2}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9QXY2}. Cell projection, axon {ECO:0000250|UniProtKB:Q9QXY2}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9QXY2}. Presynapse {ECO:0000250|UniProtKB:Q9QXY2}. Postsynapse {ECO:0000250|UniProtKB:Q9QXY2}. Postsynaptic density {ECO:0000250|UniProtKB:Q9QXY2}. Note=Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and enriched in postsynaptic density fractions. {ECO:0000250|UniProtKB:Q9QXY2}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |