| Gene Information | |
|---|---|
| Gene Name | RWDD3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 267 |
| Protein Names | RWD domain-containing protein 3 (RWD domain-containing sumoylation enhancer) (RSUME) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000122481 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y3V2 |
| Gene Card | RWDD3 |
| Uniprot ID | Q9Y3V2 |
| Pfam | PF05773 |
| In ASD | no |
| Allosteric Prediction | no (-0.88297824) |
| Ortholog in Animals | Alpaca_ RWDD3 ( ortholog_one2one ) Dog_ RWDD3 ( ortholog_one2one ) GuineaPig_ RWDD3 ( ortholog_one2one ) Macaque_ RWDD3 ( ortholog_one2one ) Mouse_ Rwdd3 ( ortholog_one2one ) Pig_ RWDD3 ( ortholog_one2one ) Rat_ Rwdd3 ( ortholog_one2one ) Rabbit_ RWDD3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in glioma tumors (at protein level). Expressed in a wide number of tissues with highest expression in cerebellum, pituitary, heart, kidney, liver, stomach, pancreas, prostate and spleen. Low levels in thalamus, spinal cord, esophagus, thymus, lung and peripheral blood leukocytes. A higher level expression seen in pituitary tumors as compared to the pituitary gland. {ECO:0000269|PubMed:17956732, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:23469069}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.1(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2EBK (NMR - ) 4Y1L (X-ray 2.70A ) |
| DBSNP | rs259358 rs2296308 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:17956732}. Cytoplasm {ECO:0000269|PubMed:17956732}. Note=Colocalizes with UBC9/UBE2I in nuclear spots. {ECO:0000269|PubMed:17956732}. |
| Mouse PG classification | NA |
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