| Gene Information | |
|---|---|
| Gene Name | ADARB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 741 |
| Protein Names | Double-stranded RNA-specific editase 1 (EC 3.5.4.37) (RNA-editing deaminase 1) (RNA-editing enzyme 1) (dsRNA adenosine deaminase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000197381 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P78563 |
| Gene Card | ADARB1 |
| Uniprot ID | P78563 |
| Pfam | PF02137; PF00035 |
| In ASD | no |
| Allosteric Prediction | no (-0.047087192) |
| Ortholog in Animals | Alpaca_ ADARB1 ( ortholog_one2one ) Dog_ ADARB1 ( ortholog_one2one ) GuineaPig_ ADARB1 ( ortholog_one2one ) Macaque_ ADARB1 ( ortholog_one2one ) Mouse_ Adarb1 ( ortholog_one2one ) Pig_ ADARB1 ( ortholog_one2one ) Rat_ Adarb1 ( ortholog_one2one ) Rabbit_ ADARB1 ( ortholog_one2one ) |
| Ohnologs | ADARB2 |
| Paralogs | TARBP2, ADAT1, ADARB2, PRKRA, ILF3, STRBP, ZFR, ADAD1, STAU2, ILF2, ZFR2, STAU1, ADAR, ADAD2 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in brain and heart and at lower levels in placenta. Fair expression in lung, liver and kidney. Detected in brain, heart, kidney, lung and liver (at protein level). {ECO:0000269|PubMed:18178553, ECO:0000269|PubMed:9149227}.; [Isoform 5]: Highly expressed in hippocampus and colon. Expressed in pediatric astrocytomas and the protein has a decreased RNA-editing activity. The decrease in RNA editing correlates with the grade of malignancy of the tumors, with the high grade tumors showing lower editing is seen. {ECO:0000269|PubMed:19156214}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1ZY7 (X-ray 1.70A ) 5ED1 (X-ray 2.77A ) 5ED2 (X-ray 2.95A ) 5HP2 (X-ray 2.98A ) 5HP3 (X-ray 3.09A ) 6D06 (X-ray 2.55A ) 6VFF (X-ray 2.80A ) 7KFN (X-ray 2.50A ) |
| DBSNP | rs199697177 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:32220291}. Nucleus, nucleolus {ECO:0000269|PubMed:32220291}. Note=Shuttles between nucleoli and the nucleoplasm. {ECO:0000305|PubMed:32220291}.; [Isoform 1]: Nucleus {ECO:0000269|PubMed:32220291}. Nucleus, nucleolus {ECO:0000269|PubMed:32220291}.; [Isoform 2]: Nucleus {ECO:0000269|PubMed:32220291}. Nucleus, nucleolus {ECO:0000269|PubMed:32220291}. |
| Mouse PG classification | NA |
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