| Gene Information | |
|---|---|
| Gene Name | PCDH19 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1148 |
| Protein Names | Protocadherin-19 |
| Target Name | protocadherin-19 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000165194 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8TAB3 |
| Gene Card | PCDH19 |
| Uniprot ID | Q8TAB3 |
| Pfam | PF00028; PF08266 |
| In ASD | no |
| Allosteric Prediction | no (-0.41607842) |
| Ortholog in Animals | Alpaca_ PCDH19 ( ortholog_one2one ) Dog_ PCDH19 ( ortholog_one2one ) GuineaPig_ PCDH19 ( ortholog_one2one ) Macaque_ PCDH19 ( ortholog_one2one ) Mouse_ Pcdh19 ( ortholog_one2one ) Pig_ PCDH19 ( ortholog_one2one ) Rat_ Pcdh19 ( ortholog_one2one ) Rabbit_ PCDH19 ( ortholog_one2one ) |
| Ohnologs | PCDHB4, PCDHA6, PCDHGA2, PCDHB2, PCDHB3, PCDHB5, PCDHB6, PCDHB7, PCDHB15, PCDH12, PCDH17, PCDHB8, PCDHB10, PCDHB14, PCDHB12, PCDH8, PCDH10, PCDHB18P, PCDHB1, PCDHB13, PCDH18, PCDHB11, PCDHGA1, PCDHA9, PCDHA8, PCDHA7, PCDHA5, PCDHA4, PCDHA2, PCDHA1 |
| Paralogs | CDHR4, PCDHGB3, PCDHGB1, PCDHGA3, PCDH17, PCDHA13, PCDHGA8, PCDHB16, PCDHA11, PCDHGB6, PCDHGC5, PCDHGC4, PCDHB9, PCDHB10, PCDHA12, PCDHA10, PCDHA9, PCDHA7, PCDHA5, PCDH10, PCDHB6, PCDH15, PCDHB13, PCDHB2, PCDHGA7, PCDHGC3, PCDHB1, PCDHGA5, PCDHA3, PCDHAC2, PCDHB4, PCDHA4, PCDHB5, PCDHGA10, PCDHGB2, PCDH8, PCDH18, PCDHGA1, PCDHGA11, PCDHGA12, PCDHGA2, PCDHB7, PCDHGB7, PCDH12, PCDHGA9, PCDHGB4, PCDHGB5, PCDHA8, PCDHA6, PCDHA2, PCDHB12, PCDHB11, PCDHB14, PCDHB8, PCDHGA4, PCDHB15, CDH16, PCDHA1, PCDHB3, PCDHAC1, PCDHGA6 |
| Tissue | NA |
| Tissue Specificity | Moderately expressed in all regions of the brain examined, with lowest levels found in the cerebellum. Moderate expression is also found in ovary, and low expression in all other tissues tested. Also detected in primary skin fibroblast. {ECO:0000269|PubMed:11549318, ECO:0000269|PubMed:18469813}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6VFU (X-ray 3.50A ) |
| DBSNP | rs1569316056 rs796052795 rs796052799 rs753757730 rs746274631 rs587784299 rs1555985475 rs1060502176 rs1555985448 rs796052839 rs1928407149 rs132630323 rs267606933 rs796052819 rs201989363 rs1221643775 rs748581653 rs3764758 rs184545774 rs191333060 rs200021840 rs141816797 |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Mouse PG classification | NA |
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