| Gene Information | |
|---|---|
| Gene Name | SPARC |
| Organism | Homo sapiens (Human) |
| Gene Length | 303 |
| Protein Names | SPARC (Basement-membrane protein 40) (BM-40) (Osteonectin) (ON) (Secreted protein acidic and rich in cysteine) |
| Target Name | sparc |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000113140 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P09486 |
| Gene Card | SPARC |
| Uniprot ID | P09486 |
| Pfam | PF09289; PF00050; PF10591 |
| In ASD | no |
| Allosteric Prediction | yes (0.469956298) |
| Ortholog in Animals | Alpaca_ SPARC ( ortholog_one2one ) Dog_ SPARC ( ortholog_one2one ) GuineaPig_ SPARC ( ortholog_one2one ) Macaque_ SPARC ( ortholog_one2one ) Mouse_ Sparc ( ortholog_one2one ) Pig_ SPARC ( ortholog_one2one ) Rat_ Sparc ( ortholog_one2one ) Rabbit_ SPARC ( ortholog_one2one ) |
| Ohnologs | SPARCL1 |
| Paralogs | SPARCL1 |
| Tissue | zone.of.skin |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1BMO (X-ray 3.10A ) 1NUB (X-ray 2.80A ) 1SRA (X-ray 2.00A ) 2V53 (X-ray 3.20A ) |
| DBSNP | rs6874468 rs13359508 rs1057517662 rs1057517663 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:2306517, ECO:0000269|PubMed:3400777, ECO:0000269|PubMed:7495300, ECO:0000269|PubMed:9457905}. Note=In or around the basement membrane. |
| Mouse PG classification | LPG |
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