| Gene Information | |
|---|---|
| Gene Name | SPAG6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 509 |
| Protein Names | Sperm-associated antigen 6 (Protein PF16 homolog) (Repro-SA-1) (Sperm flagellar protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000077327 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O75602 |
| Gene Card | SPAG6 |
| Uniprot ID | O75602 |
| Pfam | PF00514 |
| In ASD | no |
| Allosteric Prediction | no (-1.423379415) |
| Ortholog in Animals | Alpaca_ SPAG6 ( ortholog_one2one ) Dog_ SPAG6 ( ortholog_one2one ) Macaque_ SPAG6 ( ortholog_one2one ) Mouse_ Spag6l ( ortholog_one2many ) Mouse_ Spag6 ( ortholog_one2many ) Pig_ SPAG6 ( ortholog_one2one ) Rat_ Spag6 ( ortholog_one2many ) Rat_ Spag6l ( ortholog_one2many ) Rabbit_ SPAG6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | testis |
| Tissue Specificity | Highly expressed in testis. {ECO:0000269|PubMed:10493827}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.032468(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7074847 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10493827}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:10493827}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9JLI7}. Note=Associated with microtubules. Detected on the sperm flagellum (PubMed:10493827). Localizes in the cilium axoneme in a SPEF1-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q9JLI7, ECO:0000269|PubMed:10493827}. |
| Mouse PG classification | NA |
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