| Gene Information | |
|---|---|
| Gene Name | SOAT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 550 |
| Protein Names | Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) |
| Target Name | sterol o-acyltransferase 1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000057252 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P35610 |
| Gene Card | SOAT1 |
| Uniprot ID | P35610 |
| Pfam | PF03062 |
| In ASD | yes |
| Allosteric Prediction | yes (1.44045046) |
| Ortholog in Animals | Alpaca_ SOAT1 ( ortholog_one2one ) Dog_ SOAT1 ( ortholog_one2one ) GuineaPig_ SOAT1 ( ortholog_one2one ) Macaque_ SOAT1 ( ortholog_one2one ) Mouse_ Soat1 ( ortholog_one2one ) Pig_ SOAT1 ( ortholog_one2one ) Rat_ Soat1 ( ortholog_one2one ) Rabbit_ SOAT1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SOAT2, DGAT1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6L47 (EM 3.50A ) 6L48 (EM 3.50A ) 6P2J (EM 3.00A ) 6P2P (EM 3.10A ) 6VUM (EM 3.67A ) |
| DBSNP | rs13306731 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:10438503, ECO:0000269|PubMed:16154994}; Multi-pass membrane protein {ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614}. |
| Mouse PG classification | NA |
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