| Gene Information | |
|---|---|
| Gene Name | SPAG17 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2223 |
| Protein Names | Sperm-associated antigen 17 (Projection protein PF6 homolog) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000155761 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q6Q759 |
| Gene Card | SPAG17 |
| Uniprot ID | Q6Q759 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.20384213) |
| Ortholog in Animals | Alpaca_ SPAG17 ( ortholog_one2one ) Dog_ SPAG17 ( ortholog_one2one ) GuineaPig_ SPAG17 ( ortholog_one2one ) Macaque_ SPAG17 ( ortholog_one2one ) Mouse_ Spag17 ( ortholog_one2one ) Pig_ SPAG17 ( ortholog_one2one ) Rat_ Spag17 ( ortholog_one2one ) Rabbit_ SPAG17 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | esophagus, testis, bone.marrow, caudate.nucleus, epididymis, locus.ceruleus, medulla.oblongata, ovary, pituitary.gland |
| Tissue Specificity | Highly expressed in testis. Expressed in organs that contain cilia-bearing cells including brain, oviduct, lung, and uterus. {ECO:0000269|PubMed:15827353}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs12133381 rs17185492 rs34366834 rs10923472 rs752115449 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q5S003}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q5S003}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q5S003}. Golgi apparatus {ECO:0000250|UniProtKB:Q5S003}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q5S003}. Note=Detected in the cytoplasm of round spermatids and in condensing spermatids. Localized to the central pair of the sperm flagellar axoneme. Colocalizes with SPAG6 on microtubules (By similarity). Localizes to the manchette in elongating spermatids (By similarity). {ECO:0000250|UniProtKB:Q5S003}. |
| Mouse PG classification | NA |
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