| Gene Information | |
|---|---|
| Gene Name | SPDL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 605 |
| Protein Names | Protein Spindly (hSpindly) (Arsenite-related gene 1 protein) (Coiled-coil domain-containing protein 99) (Rhabdomyosarcoma antigen MU-RMS-40.4A) (Spindle apparatus coiled-coil domain-containing protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000040275 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q96EA4 |
| Gene Card | SPDL1 |
| Uniprot ID | Q96EA4 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.49194521) |
| Ortholog in Animals | Alpaca_ SPDL1 ( ortholog_one2one ) Dog_ SPDL1 ( ortholog_one2one ) GuineaPig_ SPDL1 ( ortholog_one2one ) Macaque_ SPDL1 ( ortholog_one2one ) Mouse_ Spdl1 ( ortholog_one2one ) Pig_ SPDL1 ( ortholog_one2one ) Rat_ Spdl1 ( ortholog_one2one ) Rabbit_ SPDL1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | BICDL1, BICDL2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 8ARF (X-ray 2.80A ) |
| DBSNP | rs3797713 rs3777084 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex. |
| Mouse PG classification | NA |
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