| Gene Information | |
|---|---|
| Gene Name | SP140 |
| Organism | Homo sapiens (Human) |
| Gene Length | 867 |
| Protein Names | Nuclear body protein SP140 (Lymphoid-restricted homolog of Sp100) (LYSp100) (Nuclear autoantigen Sp-140) (Speckled 140 kDa) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000079263 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q13342 |
| Gene Card | SP140 |
| Uniprot ID | Q13342 |
| Pfam | PF00439; PF03172; PF01342 |
| In ASD | no |
| Allosteric Prediction | no (-0.518269168) |
| Ortholog in Animals | Alpaca_ SP140 ( ortholog_one2one ) Macaque_ SP140 ( ortholog_one2one ) Mouse_ Sp100 ( ortholog_one2one ) Pig_ SP140 ( ortholog_one2one ) Rat_ Sp100 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HMGB2, UBTF, TOX4, UBTFL1, HMGB1P1, HMGB1, SP100, SMARCE1, HMGB3, HMG20A, TFAM, HMG20B, SSRP1, TOX2, TOX, SP110, HMGB4, SP140L, HMGXB4, TOX3 |
| Tissue | appendix, lymph.node, spleen, tonsil |
| Tissue Specificity | High levels in spleen and peripheral blood leukocytes, much lower levels in tonsils, thymus, prostate, ovary, small intestine, and colon (PubMed:8695863, PubMed:8910577.) Very low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas (PubMed:8910577). Not detected in brain, liver and muscle (PubMed:8695863). {ECO:0000269|PubMed:8695863, ECO:0000269|PubMed:8910577}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2MD7 (NMR - ) 2MD8 (NMR - ) 6G8R (X-ray 2.74A ) |
| DBSNP | rs3820975 rs4972945 rs4972946 rs11887179 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:8695863, ECO:0000269|PubMed:8910577}. Nucleus, PML body {ECO:0000269|PubMed:8695863, ECO:0000269|PubMed:8910577}. Cytoplasm {ECO:0000269|PubMed:8695863}. Note=Localized to nuclear structures termed LANDS, for LYSp100-associated nuclear domains. LANDS are globular, electron-dense structures most often found in the nucleoplasm, but also found at the nuclear membrane and in the cytoplasm, suggesting that these structures may traffic between the cytoplasm and the nucleus (PubMed:8695863). Also colocalizes with PML in a subset of PML nuclear bodies (PubMed:8910577). {ECO:0000269|PubMed:8695863, ECO:0000269|PubMed:8910577}. |
| Mouse PG classification | NA |
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