| Gene Information | |
|---|---|
| Gene Name | SP100 |
| Organism | Homo sapiens (Human) |
| Gene Length | 879 |
| Protein Names | Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000067066 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P23497 |
| Gene Card | SP100 |
| Uniprot ID | P23497 |
| Pfam | PF00505; PF09011; PF03172; PF01342 |
| In ASD | no |
| Allosteric Prediction | yes (0.151323351) |
| Ortholog in Animals | Alpaca_ SP100 ( ortholog_one2one ) Dog_ SP100 ( ortholog_one2one ) Macaque_ SP100 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SP140, HMGB2, UBTF, TOX4, UBTFL1, HMGB1P1, HMGB1, SMARCE1, HMGB3, HMG20A, TFAM, HMG20B, SSRP1, TOX2, TOX, SP110, HMGB4, SP140L, HMGXB4, TOX3 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Sp100-B is expressed only in spleen, tonsil, thymus, mature B-cell line and some T-cell line, but not in brain, liver, muscle or non-lymphoid cell lines. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1H5P (NMR - ) 4PTB (X-ray 1.60A ) 5FB0 (X-ray 2.70A ) 5FB1 (X-ray 2.10A ) 5PWE (X-ray 1.69A ) 5PWF (X-ray 1.48A ) 5PWG (X-ray 1.46A ) 5PWH (X-ray 1.50A ) 5PWI (X-ray 1.62A ) 5PWJ (X-ray 1.89A ) 5PWK (X-ray 1.62A ) 5PWL (X-ray 1.83A ) 5PWM (X-ray 1.54A ) 5PWN (X-ray 1.64A ) 5PWO (X-ray 1.85A ) 5PWP (X-ray 1.51A ) 5PWQ (X-ray 1.52A ) 5PWR (X-ray 1.46A ) 5PWS (X-ray 1.40A ) 5PWT (X-ray 1.58A ) 5PWU (X-ray 1.44A ) 5PWV (X-ray 1.58A ) 5PWW (X-ray 1.59A ) 5PWX (X-ray 1.69A ) 5PWY (X-ray 1.98A ) 5PWZ (X-ray 1.62A ) 5PX0 (X-ray 1.55A ) 5PX1 (X-ray 1.55A ) 5PX2 (X-ray 1.43A ) 5PX3 (X-ray 1.57A ) 5PX4 (X-ray 1.45A ) 5PX5 (X-ray 1.74A ) 5PX6 (X-ray 1.43A ) 5PX7 (X-ray 1.74A ) 5PX8 (X-ray 1.71A ) 5PX9 (X-ray 1.89A ) 5PXA (X-ray 1.43A ) 5PXB (X-ray 1.46A ) 5PXC (X-ray 1.52A ) 5PXD (X-ray 1.64A ) 5PXE (X-ray 1.55A ) 5PXF (X-ray 1.71A ) 5PXG (X-ray 1.98A ) 5PXH (X-ray 2.25A ) 5PXI (X-ray 1.76A ) 5PXJ (X-ray 1.68A ) 5PXK (X-ray 1.98A ) 5PXL (X-ray 1.35A ) 5PXM (X-ray 1.59A ) 5PXN (X-ray 1.43A ) 5PXO (X-ray 1.78A ) 5PXP (X-ray 1.86A ) 5PXQ (X-ray 1.62A ) 5PXR (X-ray 1.81A ) 5PXS (X-ray 1.49A ) 5PXT (X-ray 1.40A ) 5PXU (X-ray 1.76A ) 5PXV (X-ray 1.65A ) 5PXW (X-ray 2.01A ) 5PXX (X-ray 1.57A ) 5PXY (X-ray 2.14A ) 5PXZ (X-ray 1.65A ) 5PY0 (X-ray 1.70A ) 5PY1 (X-ray 1.74A ) 5PY2 (X-ray 1.62A ) 5PY3 (X-ray 1.78A ) 5PY4 (X-ray 1.67A ) 5PY5 (X-ray 1.44A ) 5PY6 (X-ray 1.74A ) 5PY7 (X-ray 1.68A ) 5PY8 (X-ray 1.66A ) 5PY9 (X-ray 1.73A ) 5PYA (X-ray 1.55A ) 5PYB (X-ray 1.74A ) 5PYC (X-ray 1.87A ) 5PYD (X-ray 2.02A ) 5PYE (X-ray 1.81A ) 5PYF (X-ray 1.83A ) 5PYG (X-ray 1.95A ) 5PYH (X-ray 1.74A ) 5PYI (X-ray 2.29A ) 5PYJ (X-ray 1.97A ) 5PYK (X-ray 1.88A ) 5PYL (X-ray 1.53A ) 5PYM (X-ray 1.70A ) 5PYN (X-ray 1.89A ) 5PYO (X-ray 1.67A ) 5PYP (X-ray 1.63A ) 5PYQ (X-ray 1.97A ) 5PYR (X-ray 1.94A ) 5PYS (X-ray 2.09A ) 5PYT (X-ray 2.13A ) 5PYU (X-ray 1.74A ) 5PYV (X-ray 1.94A ) 5PYW (X-ray 1.45A ) 5PYX (X-ray 1.57A ) 5PYY (X-ray 1.64A ) 5PYZ (X-ray 1.59A ) 5PZ0 (X-ray 2.13A ) 5PZ1 (X-ray 2.13A ) 5PZ2 (X-ray 1.88A ) 5PZ3 (X-ray 1.93A ) 5PZ4 (X-ray 1.94A ) 5PZ5 (X-ray 2.64A ) 5PZ6 (X-ray 1.87A ) 5PZ7 (X-ray 1.54A ) 5PZ8 (X-ray 1.52A ) 5PZ9 (X-ray 2.01A ) 5PZA (X-ray 1.59A ) 5PZB (X-ray 2.05A ) 5PZC (X-ray 1.61A ) 5PZD (X-ray 1.74A ) 5PZE (X-ray 1.82A ) 5PZF (X-ray 1.84A ) 5PZG (X-ray 1.88A ) 5PZH (X-ray 1.63A ) 5PZI (X-ray 1.62A ) 5PZJ (X-ray 1.72A ) 6G5N (X-ray 1.76A ) 6G5P (X-ray 1.35A ) |
| DBSNP | rs12724 rs34700604 |
| Subcellular location [CC] | Nucleus. Nucleus, PML body {ECO:0000269|PubMed:27211601}. Cytoplasm. Note=Differences in the subnuclear localization of the different isoforms seem to exist and may also be cell cycle- and interferon-dependent. Accumulates in the cytoplasm upon FAS activation.; [Isoform Sp100-C]: Nucleus {ECO:0000269|PubMed:11313457}. Note=Forms a reticulate or track-like nuclear pattern with denser concentrations at the nuclear lamina and surrounding the nucleoli, a pattern reminiscent of heterochromatin-rich regions according to PubMed:11313457. |
| Mouse PG classification | NA |
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