| Gene Information | |
|---|---|
| Gene Name | SP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 785 |
| Protein Names | Transcription factor Sp1 |
| Target Name | transcription factor sp1 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000185591 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P08047 |
| Gene Card | SP1 |
| Uniprot ID | P08047 |
| Pfam | PF00096 |
| In ASD | no |
| Allosteric Prediction | yes (1.1301577) |
| Ortholog in Animals | Alpaca_ SP1 ( ortholog_one2one ) Dog_ SP1 ( ortholog_one2one ) GuineaPig_ SP1 ( ortholog_one2one ) Macaque_ SP1 ( ortholog_one2one ) Mouse_ Sp1 ( ortholog_one2one ) Pig_ SP1 ( ortholog_one2one ) Rat_ Sp1 ( ortholog_one2one ) Rabbit_ SP1 ( ortholog_one2one ) |
| Ohnologs | SP2, SP4, SP3 |
| Paralogs | SP3, SP2, SP4 |
| Tissue | NA |
| Tissue Specificity | Up-regulated in adenocarcinomas of the stomach (at protein level). Isoform 3 is ubiquitously expressed at low levels. {ECO:0000269|PubMed:21798247}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002768(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1SP1 (NMR - ) 1SP2 (NMR - ) 1VA1 (NMR - ) 1VA2 (NMR - ) 1VA3 (NMR - ) 6PV0 (NMR - ) 6PV1 (NMR - ) 6PV2 (NMR - ) 6PV3 (NMR - ) 6UCO (NMR - ) 6UCP (NMR - ) |
| DBSNP | rs3741665 |
| Subcellular location [CC] | Nucleus. Cytoplasm. Note=Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location. |
| Mouse PG classification | NA |
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