| Gene Information | |
|---|---|
| Gene Name | USP21 |
| Organism | Homo sapiens (Human) |
| Gene Length | 565 |
| Protein Names | Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000143258 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UK80 |
| Gene Card | USP21 |
| Uniprot ID | Q9UK80 |
| Pfam | PF00443 |
| In ASD | no |
| Allosteric Prediction | no (-0.101121303) |
| Ortholog in Animals | Alpaca_ USP21 ( ortholog_one2one ) Dog_ USP21 ( ortholog_one2one ) GuineaPig_ USP21 ( ortholog_one2one ) Macaque_ USP21 ( ortholog_one2one ) Mouse_ Usp21 ( ortholog_one2one ) Pig_ USP21 ( ortholog_one2one ) Rat_ Usp21 ( ortholog_one2one ) Rabbit_ USP21 ( ortholog_one2one ) |
| Ohnologs | USP2, USP3 |
| Paralogs | USP11, USP20, USP4, USP5, USP42, USP14, USP29, USP25, USP48, USP2, USP47, USP40, USP3, USP1, USP34, USP8, USP24, USP38, USP32, USP6, USP31, USP50, USP13, USP7, USP43, USP17L4, USP17L11, USP17L27, USP17L22, USP17L30, USP17L17, USP17L26, USP17L25, USP17L12, USP17L10, USP17L28, USP17L1, USP17L5, USP17L24, USP17L21, USP17L3, USP17L29, USP17L18, USP17L13, USP17L15, USP17L7, USP17L23, USP17L2, USP17L20, USP17L8, USP17L19, USP35, USP45, USP33, USP49, USP51, USP19, USP15, USP28, USP9X, USP9Y, USP27X, USP44, USP18, USP30, USP10, USP22, USP26, USP16, USP37, USP36 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung. {ECO:0000269|PubMed:10799498}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2Y5B (X-ray 2.70A ) 3I3T (X-ray 2.59A ) 3MTN (X-ray 2.70A ) |
| DBSNP | rs34779722 rs17356051 rs1127525 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:21888622}. Nucleus {ECO:0000269|PubMed:21888622}. |
| Mouse PG classification | NA |
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