| Gene Information | |
|---|---|
| Gene Name | SOX2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 317 |
| Protein Names | Transcription factor SOX-2 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000181449 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P48431 |
| Gene Card | SOX2 |
| Uniprot ID | P48431 |
| Pfam | PF00505; PF12336 |
| In ASD | no |
| Allosteric Prediction | no (-0.113633173) |
| Ortholog in Animals | Alpaca_ SOX2 ( ortholog_one2one ) Mouse_ Sox2 ( ortholog_one2one ) Pig_ SOX2 ( ortholog_one2one ) Rat_ Sox2 ( ortholog_one2one ) |
| Ohnologs | SOX3, SOX1, SOX14 |
| Paralogs | SOX12, SOX17, SOX13, SOX30, CFAP65, SOX21, SOX8, SOX7, SOX5, SOX14, SOX6, SOX9, SRY, SOX10, SOX1, SOX4, SOX18, SOX11, SOX3, SOX15 |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002190(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1O4X (NMR - ) 2LE4 (NMR - ) 6T7B (EM 5.10A ) 6T90 (EM 3.05A ) 6WX7 (X-ray 2.70A ) 6WX8 (X-ray 2.30A ) 6WX9 (X-ray 2.80A ) 6YOV (EM 3.42A ) |
| DBSNP | rs104893805 |
| Subcellular location [CC] | Nucleus speckle {ECO:0000250|UniProtKB:Q05066}. Cytoplasm {ECO:0000250|UniProtKB:Q05738}. Nucleus {ECO:0000250|UniProtKB:Q05738}. Note=Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity). Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity). Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (By similarity). {ECO:0000250|UniProtKB:Q05066, ECO:0000250|UniProtKB:Q05738}. |
| Mouse PG classification | HPG |
| click here to return to the previous page | |