| Gene Information | |
|---|---|
| Gene Name | VPS16 |
| Organism | Homo sapiens (Human) |
| Gene Length | 839 |
| Protein Names | Vacuolar protein sorting-associated protein 16 homolog (hVPS16) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000215305 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H269 |
| Gene Card | VPS16 |
| Uniprot ID | Q9H269 |
| Pfam | PF04840; PF04841 |
| In ASD | no |
| Allosteric Prediction | no (-1.000803187) |
| Ortholog in Animals | Alpaca_ VPS16 ( ortholog_one2one ) Dog_ VPS16 ( ortholog_one2one ) GuineaPig_ VPS16 ( ortholog_one2one ) Macaque_ VPS16 ( ortholog_one2one ) Mouse_ Vps16 ( ortholog_one2one ) Pig_ VPS16 ( ortholog_one2one ) Rat_ Vps16 ( ortholog_one2one ) Rabbit_ VPS16 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.255279(Mouse);0.441207(Rat);0.182762(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4BX9 (X-ray 2.60A ) |
| DBSNP | rs367642720 rs35773586 |
| Subcellular location [CC] | Late endosome membrane {ECO:0000269|PubMed:17897319}; Peripheral membrane protein {ECO:0000269|PubMed:17897319}; Cytoplasmic side {ECO:0000269|PubMed:17897319}. Lysosome membrane {ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:21802320}; Peripheral membrane protein {ECO:0000269|PubMed:17897319}; Cytoplasmic side {ECO:0000269|PubMed:17897319}. Early endosome {ECO:0000269|PubMed:18552835}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q920Q4}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:24554770}. Note=Colocalizes with AP-3, clathrin, Rab5 and Rab7b (By similarity). Cytoplasmic, peripheral membrane protein associated with early endosomes and late endosomes/lysosomes. {ECO:0000250|UniProtKB:Q920Q4, ECO:0000305}. |
| Mouse PG classification | NA |
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