| Gene Information | |
|---|---|
| Gene Name | KCNG3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 436 |
| Protein Names | Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv10.1) (Voltage-gated potassium channel subunit Kv6.3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000171126 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8TAE7 |
| Gene Card | KCNG3 |
| Uniprot ID | Q8TAE7 |
| Pfam | PF02214; PF00520 |
| In ASD | no |
| Allosteric Prediction | no (-0.393262103) |
| Ortholog in Animals | Alpaca_ KCNG3 ( ortholog_one2one ) Dog_ KCNG3 ( ortholog_one2one ) GuineaPig_ KCNG3 ( ortholog_one2one ) Macaque_ KCNG3 ( ortholog_one2one ) Mouse_ Kcng3 ( ortholog_one2one ) Pig_ KCNG3 ( ortholog_one2one ) Rat_ Kcng3 ( ortholog_one2one ) Rabbit_ KCNG3 ( ortholog_one2one ) |
| Ohnologs | KCNS2, KCNV1, KCNB2 |
| Paralogs | KCNS1, KCND1, KCNA7, KCNB2, KCNQ1, KCNQ3, KCNC4, KCNV1, KCNA1, KCNQ4, KCNA10, KCNC3, KCNV2, KCND3, KCNQ2, KCNB1, KCNA6, KCNA2, KCNA5, KCNG1, KCND2, KCNC1, KCNC2, KCNA4, KCNA3, KCNQ5, KCNF1, KCNG2, KCNG4, KCNS3, KCNS2 |
| Tissue | NA |
| Tissue Specificity | Expressed in the brain, liver, testis, small intestine, colon, thymus and adrenal gland (PubMed:11852086, PubMed:12060745). {ECO:0000269|PubMed:11852086, ECO:0000269|PubMed:12060745}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:11852086, ECO:0000269|PubMed:12060745, ECO:0000269|PubMed:19074135}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:12060745}. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane (PubMed:12060745). Colocalizes with KCNB1 at the plasma membrane (PubMed:12060745, PubMed:19074135). Remains intracellular in the absence of KCNB1 (PubMed:12060745). {ECO:0000269|PubMed:12060745, ECO:0000269|PubMed:19074135}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |