| Gene Information | |
|---|---|
| Gene Name | ITK |
| Organism | Homo sapiens (Human) |
| Gene Length | 620 |
| Protein Names | Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) |
| Target Name | tyrosine-protein kinase itk/tsk |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000113263 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q08881 |
| Gene Card | ITK |
| Uniprot ID | Q08881 |
| Pfam | PF00779; PF00169; PF07714; PF00017; PF00018 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000061444) |
| Ortholog in Animals | Alpaca_ ITK ( ortholog_one2one ) Dog_ ITK ( ortholog_one2one ) GuineaPig_ ITK ( ortholog_one2one ) Macaque_ ITK ( ortholog_one2one ) Mouse_ Itk ( ortholog_one2one ) Pig_ ITK ( ortholog_one2one ) Rat_ Itk ( ortholog_one2one ) Rabbit_ ITK ( ortholog_one2one ) |
| Ohnologs | BTK, BMX, TXK, TEC |
| Paralogs | FGR, FRK, JAK3, BMX, FER, BTK, FES, BLK, JAK1, PTK2B, SYK, TYK2, LYN, ZAP70, TXK, TNK2, PTK2, SRMS, TEC, CSK, STYK1, YES1, LCK, SRC, JAK2, MATK, TNK1, HCK, ABL1, ABL2, FYN, PTK6 |
| Tissue | appendix, lymph.node, spleen, tonsil |
| Tissue Specificity | T-cell lines and natural killer cell lines. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001823(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1SM2 (X-ray 2.30A ) 1SNU (X-ray 2.50A ) 1SNX (X-ray 3.20A ) 2E6I (NMR - ) 2LMJ (NMR - ) 2YUQ (NMR - ) 3MIY (X-ray 1.67A ) 3MJ1 (X-ray 1.72A ) 3MJ2 (X-ray 1.90A ) 3QGW (X-ray 2.10A ) 3QGY (X-ray 2.10A ) 3T9T (X-ray 1.65A ) 3V5J (X-ray 2.59A ) 3V5L (X-ray 1.86A ) 3V8T (X-ray 2.00A ) 3V8W (X-ray 2.27A ) 4HCT (X-ray 1.48A ) 4HCU (X-ray 1.43A ) 4HCV (X-ray 1.48A ) 4KIO (X-ray 2.18A ) 4L7S (X-ray 2.03A ) 4M0Y (X-ray 1.70A ) 4M0Z (X-ray 2.00A ) 4M12 (X-ray 2.15A ) 4M13 (X-ray 1.85A ) 4M14 (X-ray 1.55A ) 4M15 (X-ray 1.52A ) 4MF0 (X-ray 2.67A ) 4MF1 (X-ray 2.11A ) 4PP9 (X-ray 2.58A ) 4PPA (X-ray 2.67A ) 4PPB (X-ray 2.82A ) 4PPC (X-ray 2.95A ) 4PQN (X-ray 1.71A ) 4QD6 (X-ray 2.45A ) 4RFM (X-ray 2.10A ) |
| DBSNP | rs17054374 rs121908191 rs779372373 rs34482255 rs56005928 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17060314}. Nucleus {ECO:0000250|UniProtKB:Q03526}. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. |
| Mouse PG classification | NA |
| click here to return to the previous page | |