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Gene Information
Gene Name
SOS1
Organism
Homo sapiens (Human)
Gene Length
1333
Protein Names
Son of sevenless homolog 1 (SOS-1)
Target Name
NA
Target Type
NA
Gene Age
454 ( ENSG00000115904 )
Evolutionary Stage
Eukaryota
AlphaFoldDB
Q07889
Gene Card
SOS1
Uniprot ID
Q07889
Pfam
PF00169; PF00617; PF00618; PF00621
In ASD
yes
Allosteric Prediction
yes (0.999891638)
Ortholog in Animals
Alpaca_ SOS1 ( ortholog_one2one )
Dog_ SOS1 ( ortholog_one2one )
GuineaPig_ SOS1 ( ortholog_one2one )
Macaque_ SOS1 ( ortholog_one2one )
Mouse_ Sos1 ( ortholog_one2one )
Pig_ SOS1 ( ortholog_one2one )
Rat_ Sos1 ( ortholog_one2one )
Rabbit_ SOS1 ( ortholog_one2one )
Ohnologs
SOS2
Paralogs
RALGDS, RASGEF1A, RASGRF2, RASGRP3, SOS2, RAPGEF3, RAPGEF6, RASGRF1, RAPGEF2, RGL1, RAPGEF1, RASGEF1B, RASGRP2, RGL2, RGL3, RALGPS1, RALGPS2, RAPGEF4, RGL4, RASGRP4, RAPGEFL1, RAPGEF5, RASGRP1, RASGEF1C
Tissue
NA
Tissue Specificity
Expressed in gingival tissues. {ECO:0000269|PubMed:11868160}.
Pharmacological Animal Models
NA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1AWE
(NMR
-
)
1BKD
(X-ray
2.80A
)
1DBH
(X-ray
2.30A
)
1NVU
(X-ray
2.20A
)
1NVV
(X-ray
2.18A
)
1NVW
(X-ray
2.70A
)
1NVX
(X-ray
3.20A
)
1Q9C
(X-ray
3.21A
)
1XD2
(X-ray
2.70A
)
1XD4
(X-ray
3.64A
)
1XDV
(X-ray
4.10A
)
2II0
(X-ray
2.02A
)
3KSY
(X-ray
3.18A
)
4NYI
(X-ray
2.96A
)
4NYJ
(X-ray
2.85A
)
4NYM
(X-ray
3.55A
)
4URU
(X-ray
2.83A
)
4URV
(X-ray
2.58A
)
4URW
(X-ray
2.76A
)
4URX
(X-ray
2.49A
)
4URY
(X-ray
2.47A
)
4URZ
(X-ray
2.24A
)
4US0
(X-ray
2.17A
)
4US1
(X-ray
2.65A
)
4US2
(X-ray
2.48A
)
5OVD
(X-ray
1.90A
)
5OVE
(X-ray
1.85A
)
5OVF
(X-ray
2.01A
)
5OVG
(X-ray
2.30A
)
5OVH
(X-ray
2.30A
)
5OVI
(X-ray
2.20A
)
5WFO
(X-ray
1.99A
)
5WFP
(X-ray
2.08A
)
5WFQ
(X-ray
2.26A
)
5WFR
(X-ray
2.46A
)
6BVI
(X-ray
1.75A
)
6BVJ
(X-ray
1.75A
)
6BVK
(X-ray
1.80A
)
6BVL
(X-ray
1.75A
)
6BVM
(X-ray
1.80A
)
6CUO
(X-ray
1.73A
)
6CUP
(X-ray
1.83A
)
6CUR
(X-ray
1.73A
)
6D55
(X-ray
1.68A
)
6D56
(X-ray
1.68A
)
6D59
(X-ray
1.70A
)
6D5E
(X-ray
1.75A
)
6D5G
(X-ray
1.92A
)
6D5H
(X-ray
1.80A
)
6D5J
(X-ray
1.75A
)
6D5L
(X-ray
1.70A
)
6D5M
(X-ray
2.08A
)
6D5V
(X-ray
2.04A
)
6D5W
(X-ray
2.48A
)
6EPL
(X-ray
2.55A
)
6EPM
(X-ray
2.50A
)
6EPN
(X-ray
2.50A
)
6EPO
(X-ray
2.40A
)
6EPP
(X-ray
2.40A
)
6F08
(X-ray
1.90A
)
6SCM
(X-ray
1.87A
)
6SFR
(X-ray
1.92A
)
6V94
(X-ray
1.80A
)
6V9F
(X-ray
1.85A
)
6V9J
(X-ray
1.76A
)
6V9L
(X-ray
1.70A
)
6V9M
(X-ray
1.65A
)
6V9N
(X-ray
1.65A
)
6V9O
(X-ray
1.80A
)
6Y44
(X-ray
1.71A
)
7AVI
(X-ray
1.93A
)
7AVL
(X-ray
1.72A
)
7AVS
(X-ray
2.28A
)
7AVT
(X-ray
1.88A
)
7AVU
(X-ray
2.10A
)
7AVV
(X-ray
2.12A
)
7KFZ
(EM
3.47A
)
7UKR
(X-ray
2.50A
)
7UKS
(X-ray
2.29A
)
DBSNP
rs150565592
rs1553362937
rs397517164
rs397517166
rs397517172
rs142094234
rs137852812
rs137852813
rs137852813
rs397517180
rs724160007
rs397517146
rs730881041
rs267607080
rs397517147
rs730881048
rs397517148
rs397517150
rs727504295
rs730881044
rs1553356111
rs1553356111
rs1431574387
rs371314838
rs397517149
rs730881046
rs397517153
rs137852814
rs397517154
rs397517154
rs267607079
rs397517154
rs200786705
rs727505093
rs56219475
rs727505381
rs140811086
rs574088829
rs1335137808
rs397517159
rs1367714753
rs8192671
rs768113420
rs375550588
rs553805862
Subcellular location [CC]
NA
Mouse PG classification
NA
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