Gene Information
Gene NameTRPM8
OrganismHomo sapiens (Human)
Gene Length1104
Protein NamesTransient receptor potential cation channel subfamily M member 8 (Long transient receptor potential channel 6) (LTrpC-6) (LTrpC6) (Transient receptor potential p8) (Trp-p8)
Target Nametransient receptor potential cation channel subfamily m member 8
Target TypeNA
Gene Age424 ( ENSG00000144481 )
Evolutionary StageVertebrata
AlphaFoldDBQ7Z2W7
Gene CardTRPM8
Uniprot IDQ7Z2W7
PfamPF00520; PF18139
In ASDyes
Allosteric Predictionyes (1.306796704)
Ortholog in AnimalsAlpaca_ TRPM8 ( ortholog_one2one )
Alpaca_ TRPM8 ( ortholog_one2many )
Dog_ TRPM8 ( ortholog_one2one )
GuineaPig_ Trpm8 ( ortholog_one2one )
Macaque_ TRPM8 ( ortholog_one2one )
Mouse_ Trpm8 ( ortholog_one2one )
Pig_ TRPM8 ( ortholog_one2one )
Rat_ Trpm8 ( ortholog_one2one )
Rabbit_ TRPM8 ( ortholog_one2one )
OhnologsTRPM2
ParalogsTRPM3, TRPM4, TRPM5, TRPM1, TRPM7, TRPM2, TRPM6
Tissueprostate, brain, liver
Tissue SpecificityExpressed in prostate. Also expressed in prostate tumors and in non-prostatic primary tumors such as colon, lung, breast and skin tumors. {ECO:0000269|PubMed:11325849, ECO:0000269|PubMed:12858355, ECO:0000269|PubMed:16174775, ECO:0000269|PubMed:22128173}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs13004520  rs17868387  rs7593557  rs28902173  rs17862932  rs28902201 
Subcellular location [CC]Cell membrane;
Multi-pass membrane protein. Membrane raft. Endoplasmic reticulum membrane. Note=Localizes to membrane rafts but is also located in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts (By similarity). Located in the endoplasmic reticulum in prostate cancer cells. {ECO:0000250}.
Mouse PG classificationNA
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